Role of Innate Immune System in the Pathogenesis of Ankylosing Spondylitis

Tehran University of Medical Sciences

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Role of Innate Immune System in the Pathogenesis of Ankylosing Spondylitis Publisher Pubmed

Vanaki N¹ ; Aslani S¹ ; Jamshidi A¹ ; Mahmoudi M¹

Show Affiliations

1. Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Biomedicine and Pharmacotherapy Published:2018

Abstract

Ankylosing Spondylitis (AS) is a debilitating rheumatic disease that gives young adults a severe form of arthritis with pain and stiffness in the axial skeleton. After the discovery of Human leukocyte antigen B27 (HLA-B27), several hypotheses have been suggested to uncover the exact etiology of AS. The tendency of HLA-B27 to form unusual structures results in recognition and activation of crucial components in innate immune system. Moreover, cellular and soluble arms of the innate response are frequently observed within the affected tissues. Genome-wide analysis has also shown the association of several innate immune-related pathways and cytokines, which act as the effective therapeutic targets in AS. Given the importance of innate immune system, we present a general overview of innate immune components and their involvement in the pathogenesis of AS. In our belief, this kind of explanation can hopefully provide new perspectives for diagnosis and treatment of these patients in the future. © 2018

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Style	Citing Format
MLA	Vanaki N, et al.. "Role of Innate Immune System in the Pathogenesis of Ankylosing Spondylitis." Biomedicine and Pharmacotherapy, vol. 105, no. , 2018, pp. 130-143.
APA	Vanaki N, Aslani S, Jamshidi A, Mahmoudi M (2018). Role of Innate Immune System in the Pathogenesis of Ankylosing Spondylitis. Biomedicine and Pharmacotherapy, 105(), 130-143.
Chicago	Vanaki N, Aslani S, Jamshidi A, Mahmoudi M. "Role of Innate Immune System in the Pathogenesis of Ankylosing Spondylitis." Biomedicine and Pharmacotherapy 105, no. (2018): 130-143.
Harvard	Vanaki N et al. (2018) 'Role of Innate Immune System in the Pathogenesis of Ankylosing Spondylitis', Biomedicine and Pharmacotherapy, 105(), pp. 130-143.
Vancouver	Vanaki N, Aslani S, Jamshidi A, Mahmoudi M. Role of Innate Immune System in the Pathogenesis of Ankylosing Spondylitis. Biomedicine and Pharmacotherapy. 2018;105():130-143.
BibTex	@article{ author = {Vanaki N and Aslani S and Jamshidi A and Mahmoudi M}, title = {Role of Innate Immune System in the Pathogenesis of Ankylosing Spondylitis}, journal = {Biomedicine and Pharmacotherapy}, volume = {105}, number = {}, pages = {130-143}, year = {2018} }
RIS	TY - JOUR AU - Vanaki N AU - Aslani S AU - Jamshidi A AU - Mahmoudi M TI - Role of Innate Immune System in the Pathogenesis of Ankylosing Spondylitis JO - Biomedicine and Pharmacotherapy VL - 105 IS - SP - 130 EP - 143 PY - 2018 ER -