Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Adaptive Immune-Related Cells and Cytokines in Spondyloarthropathies Publisher



Akhtari M1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Ankylosing Spondylitis - Axial Spondyloarthritis: Cellular# Molecular and Environmental Factors Published:2021


Abstract

Spondyloarthropathies (SpAs) including ankylosing spondylitis (AS), inflammatory bowel disease (IBD) associated arthritis, psoriatic arthritis (PsA), reactive arthritis (ReA), and undifferentiated spondyloarthropathies (uSpAs) are a subset of disorders with strong adaptive and inflammatory innate immunity overlaps. The immunopathology of this group of rheumatic diseases is related to MHC class-I molecule and adaptive immune responses. Adaptive immunity is composed of specialized T and B cell lineage lymphocytes and includes both humoral and cell-mediated immune mechanisms. T lymphocytes are divided into the CD4+ (helper T) and CD8+ (cytotoxic T) cells based on the surface receptors. Based on the secretory cytokines, helper T cells are sorted into Th1, Th2, Th17, Th22, and regulatory T lymphocytes (Treg) and cytotoxic T cells (CTL) are sorted into Tc1, Tc2, and Tc17. A pathogenic role of Th17 and Th22, the defect in the regulatory function of Treg lymphocytes, dysregulated Th1 and Th2 function, aberrant cytotoxicity function of T CD8+, and abnormal B cells activity have been described to be associated with the pathogenesis of SpAs. In this chapter, we discuss recent findings regarding the pathogenic role of adaptive immunity in SpA disorders. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2022.
Related Docs
View other Related Docs
1. Immune Cells Involved in the Pathogenesis of Ankylosing Spondylitis, Biomedicine and Pharmacotherapy (2018)
2. Potential Roles for B Cells and Autoantibodies in Ankylosing Spondylitis, Current Rheumatology Reviews (2024)
3. Assessment of Immunological Profile in Ankylosing Spondylitis Patients Following a Clinical Trial With Guluronic Acid (G2013), As a New Nsaid With Immunomodulatory Properties, Immunologic Research (2019)
4. Role of Innate Immune System in the Pathogenesis of Ankylosing Spondylitis, Biomedicine and Pharmacotherapy (2018)
5. Th22 Cells Contribution in Immunopathogenesis of Rheumatic Diseases, Iranian Journal of Allergy# Asthma and Immunology (2015)
6. The Newly Identified T Helper 22 Cells Lodge in Leukemia, International Journal of Hematology-Oncology and Stem Cell Research (2015)
7. Autoimmune Diseases, Clinical Immunology (2022)
8. Oral Administration Effects of Β-D-Mannuronic Acid (M2000) on Th17 and Regulatory T Cells in Patients With Ankylosing Spondylitis, Biomedicine and Pharmacotherapy (2018)
Experts (# of related papers)
View all Related Experts
Mahdi Mahmoudi (11)
Nima Rezaei (8)
Other Related Docs
9. Innate Immune-Related Cells and Cytokines in Spondyloarthropathies, Ankylosing Spondylitis - Axial Spondyloarthritis: Cellular# Molecular and Environmental Factors (2021)
10. Copy Number Variation of Il17ra Gene and Its Association With the Ankylosing Spondylitis Risk in Iranian Patients: A Case-Control Study, BMC Medical Genetics (2020)
11. New Insights Toward the Pathogenesis of Ankylosing Spondylitis; Genetic Variations and Epigenetic Modifications, Modern Rheumatology (2017)
12. T-Helper 22 Cells As a New Player in Chronic Inflammatory Skin Disorders, International Journal of Dermatology (2015)
13. Ankylosing Spondylitis and Mesenchymal Stromal/Stem Cell Therapy: A New Therapeutic Approach, Biomedicine and Pharmacotherapy (2019)
14. An Overview to Ankylosing Spondylitis and Spondyloarthropathies, Ankylosing Spondylitis - Axial Spondyloarthritis: Cellular# Molecular and Environmental Factors (2021)
15. Cytokine Alterations in Psoriasis: An Updated Review, Expert Review of Clinical Immunology (2021)
16. Il23r Gene Polymorphism With Juvenile Idiopathic Arthritis and Its Association With Serum Il-17A, International Journal of Rheumatic Diseases (2016)
17. Immunopathogenesis of Ankylosing Spondylitis: An Updated Review, Acta Medica Iranica (2018)
18. Ankylosing Spondylitis Monocyte-Derived Macrophages Express Increased Level of A2a Adenosine Receptor and Decreased Level of Ectonucleoside Triphosphate Diphosphohydrolase-1 (Cd39), A1 and A2b Adenosine Receptors, Clinical Rheumatology (2018)
19. Il-22 Produced by T Helper Cell 22 As a New Player in the Pathogenesis of Immune Thrombocytopenia, Endocrine# Metabolic and Immune Disorders - Drug Targets (2015)
20. Emerging Therapeutic Potential of Regulatory T (Treg) Cells for Rheumatoid Arthritis: New Insights and Challenges, International Immunopharmacology (2022)
21. Identification, Isolation, and Functional Assay of Regulatory T Cells, Immunological Investigations (2016)
22. Autoimmunity As a Target for Chimeric Immune Receptor Therapy: A New Vision to Therapeutic Potential, Blood Reviews (2020)
23. Analysis of Helios Gene Expression and Foxp3 Tsdr Methylation in the Newly Diagnosed Rheumatoid Arthritis Patients, Immunological Investigations (2018)
24. The Potential Role of T Helper Cell 22 and Il-22 in Immunopathogenesis of Multiple Sclerosis, Innovations in Clinical Neuroscience (2016)
25. Efficacy and Safety of Immune Checkpoint Inhibitors and Cytokine Therapy in Autoimmune Diseases, Translational Autoimmunity: Treatment of Autoimmune Diseases (2022)
26. Adoptive Treg Cell-Based Immunotherapy: Frontier Therapeutic Aspects in Rheumatoid Arthritis, Immunotherapy (2020)
27. Clinical and Diagnostic Potential of Regulatory T Cell Markers: From Bench to Bedside, Transplant Immunology (2022)
28. High Frequency of Tc22 and Th22 Cells in Myasthenia Gravis Patients and Their Significant Reduction After Thymectomy, NeuroImmunoModulation (2018)
29. Evaluation of Il-17 Producing Memory Regulatory and Effector T Cells Expressing Cd26 Molecule in Patients With Psoriasis, Iranian Journal of Allergy# Asthma and Immunology (2018)
30. Association Between Rs6759298 and Ankylosing Spondylitis in Iranian Population, Avicenna Journal of Medical Biotechnology (2018)
31. Determination of Il-23 Receptor Expression and Gene Polymorphism (Rs1884444) in Iranian Patients With Ankylosing Spondylitis, BMC Rheumatology (2024)
32. Prophylactic Dna Vaccine Targeting Foxp3+ Regulatory T Cells Depletes Myeloid-Derived Suppressor Cells and Improves Anti-Melanoma Immune Responses in a Murine Model, Cancer Immunology# Immunotherapy (2018)
33. Evaluation of the Ankylosing Spondylitis Transcriptome for Oxidative Phosphorylation Pathway: The Shared Pathway With Neurodegenerative Diseases, Iranian Journal of Allergy# Asthma and Immunology (2021)
34. Role of Toll-Like Receptor 4 in Diabetic Retinopathy, Pharmacological Research (2022)
35. Altered Microrna Expression and Immunosuppressive Cytokine Production by Regulatory T Cells of Ulcerative Colitis Patients, Immunological Investigations (2016)
36. Promoter Hypermethylation of Bcl11b Gene Correlates With Downregulation of Gene Transcription in Ankylosing Spondylitis Patients, Genes and Immunity (2017)
37. The Role of T Helper 17 and Regulatory T Cells in Tumor Microenvironment, Immunopharmacology and Immunotoxicology (2019)
38. Immunopathogenesis of Multiple Sclerosis: Molecular and Cellular Mechanisms and New Immunotherapeutic Approaches, Immunopharmacology and Immunotoxicology (2024)
39. Regulatory T Cells in Breast Cancer As a Potent Anti-Cancer Therapeutic Target, International Immunopharmacology (2020)
40. Pd-1/Pd-L and Autoimmunity: A Growing Relationship, Cellular Immunology (2016)
41. Features and Roles of T Helper 22 Cells in Immunological Diseases and Malignancies, Scandinavian Journal of Immunology (2021)
42. The Paradox of Th17 Cell Functions in Tumor Immunity, Cellular Immunology (2017)
43. Cell-Mediated Immunity, Encyclopedia of Infection and Immunity (2022)
44. Mesenchymal Stem Cells Induce Expansion of Regulatory T Cells in Abortion-Prone Mice, Reproduction (2021)
45. Pain in Ankylosing Spondylitis: A Neuro-Immune Collaboration, Nature Reviews Rheumatology (2017)
46. The Roles of Cd4+ T-Cells in Tumor Immunity, Cancer Immunology: A Translational Medicine Context# Second Edition (2020)
47. Aryl Hydrocarbon Receptor Gene Expression in Ankylosing Spondylitis and Its Correlation With Interleukin-17, Rar-Related Orphan Receptor Gamma T Expression, and Disease Activity Indices, Archives of Rheumatology (2024)
48. The Potent Suppressive Effect of Β-D-Mannuronic Acid (M2000) on Molecular Expression of the Tlr/Nf-Kb Signaling Pathway in Ankylosing Spondylitis Patients, International Immunopharmacology (2017)
49. Association Study of Copy Number Variation in Bmp8a Gene With the Risk of Ankylosing Spondylitis in Iranian Population, Journal of Cellular Biochemistry (2019)