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Oxygen-Generating Biomaterials: A New, Viable Paradigm for Tissue Engineering? Publisher Pubmed



Gholipourmalekabadi M1, 2 ; Zhao S3 ; Harrison BS3 ; Mozafari M4 ; Seifalian AM5, 6
Authors
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Authors Affiliations
  1. 1. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States
  4. 4. Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), Tehran, Iran
  5. 5. Centre of Nanotechnology and Regenerative Medicine, University College London Medical School, London, United Kingdom
  6. 6. NanoRegMed Ltd, The London Innovation BioScience Centre, London, United Kingdom

Source: Trends in Biotechnology Published:2016


Abstract

There have been many attempts to provide sufficient nutrients, especially oxygen, to engineered large tissues to overcome the effects of hypoxia or poor vascularization. Delivering sufficient oxygen to the transplanted cells is one of the most critical issues that affects cell survival and correct maturation of engineered tissues. An emerging approach is using 3D scaffolds made from oxygen-generating biomaterials to tackle transport limitations deep within the engineered tissues. This class of biomaterials has opened a new window for overcoming the challenges associated with ischemia occurring within large tissue constructs. This review critically assesses oxygen-generating reagents, the main approaches for developing oxygen-generating biomaterials, and their potential as 3D scaffolds for regenerative medicine in a clinical setting. © 2016 Elsevier Ltd
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