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Oxygen-Generating Nanobiomaterials for the Treatment of Diabetes: A Tissue Engineering Approach Publisher



Gholipourmalekabadi M1 ; Jajarmi V1, 2 ; Rezvani Z3 ; Ghaffari M4 ; Verma KD5 ; Shirinzadeh H6 ; Mozafari M3
Authors
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Authors Affiliations
  1. 1. Biotechnology Department, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), Tehran, Iran
  4. 4. Biomaterials Group, Faculty of Biomedical Engineering (Center of Excellence), Amirkabir University of Technology, Tehran, Iran
  5. 5. Department of Physics, S.V. (P.G.) College, Aligarh, Uttar Pradesh, India
  6. 6. Device Fabrication Group, Semiconductors Department, Materials and Energy Research Center (MERC), Tehran, Iran

Source: Nanobiomaterials in Soft Tissue Engineering: Applications of Nanobiomaterials Published:2016


Abstract

In tissue engineering systems, high nutrient demand of cells following transplantation is one of the major problems with the transplantation of cells. Revolutionary techniques have been recently reported to locally deliver oxygen to beta cells, toward the goal of developing an alternative site to house insulin-producing cells. The generation of oxygen by nanobiomaterials creates a nutrient-rich environment with sustained oxygen supplementation. By adjusting different nanobiomaterials, the duration and amount of oxygen can be controlled, thereby providing the ideal environment for the cells. Recent studies showed that oxygen-generating nanobiomaterials are able to provide the supplemental oxygen needed by the islets and serve as a bridge until the blood vessels are formed, providing natural oxygen delivery to the insulin-producing cells. This chapter discusses the details of this important approach, which aims to improve the survival of transplanted cellular products by sustained oxygen delivery within the microenvironment of tissue-engineered sites. © 2016 Elsevier Inc. All rights reserved.
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