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All-Solid-State Citalopram Sensor and Its Application for the Analysis of Pharmaceutical Formulations



Ganjali MR1, 2 ; Larijani B3
Authors
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Authors Affiliations
  1. 1. Center of Excellence in Electrochemistry, University of Tehran, Tehran, Iran
  2. 2. Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Analytical and Bioanalytical Electrochemistry Published:2015

Abstract

Citalopram (CP), which is a selective serotonin reuptake inhibitor (SSRI), is used for the treatment depression. Due to the importance of the analysis of this compound, an all-solid-state polymeric membrane electrode (ASS-PME) has been devised using an ion-pair agent as the sensing element of the device. The experimental results proved that the best sensor response is observed using membranes including 7%wt CP-tetraphenyl borate (the sensing element), 57%wt dibutyl phthalate as the solvent mediator, 33%wt poly(vinyl chloride) and 3%wt of an ionic liquid. The ASS element of the device is a conductive composite of graphite, multiwall carbon nanotubes (MWCNTs), and epoxy resin which is coated on a Cu wire, which is finally coated with a thin film of the PME. The response of the ASS-PME was linear in the range of 1.0×10-7 to 1.0×10-3 mol L-1 and reached the slope of 57.3±0.3 mV/decade under optimal conditions. The experiments revealed that the optimized Citalopram ASS-PME is applicable in the quality control analyses, which was validated by its application for measurement of Citalopram in its tablets. © 2015 by CEE (Center of Excellence in Electrochemistry).