Pramipexole Symmetric and Asymmetric Potentiometric Pvc Membrane Sensors Publisher



Faridbod F¹ ; Jamshidpour T¹ ; Ganjali MR^{1, 2}
Source: International Journal of Electrochemical Science Published:2016

Abstract

Pramipexole is one of the prescribed medication for Parkinson's disease, which is a dopamine agonist of the non-ergoline class. Due to the importance of the drug, the analysis of its active ingredient in formulation is of great importance. Here, a PVC membrane sensor was made for the measurement of Pramipexole active ingredient in some pharmaceutical tablets. The PVC membrane containing ion-pair compound of Pramipexol-tetraphenyl borate as a sensing material was placed at the end of a plastic tube (as symmetric electrode) and coated on a graphite and a copper wire electrodes (as asymmetric electrodes). The polymeric membrane was plasticized by dibutyl phthalate (DBP). A wide linear range of 1.0×10-6-1.0×10-1 mol L-1 were provided by three sensors. Applicable pH range of the sensor is 3.0-6.8. Finally, the method was validated in the analysis of Pramipexole in pharmaceutical formulation. © 2016 The Authors.