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Optimized Doxycycline-Loaded Niosomal Formulation for Treatment of Infection-Associated Prostate Cancer: An In-Vitro Investigation Publisher



Akbarzadeh I1 ; Tavakkoli Yaraki M2, 3 ; Bourbour M4 ; Noorbazargan H5 ; Lajevardi A6 ; Sadat Shilsar SM7 ; Heidari F8 ; Mousavian SM9
Authors
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Authors Affiliations
  1. 1. Department of Chemical and Petrochemical Engineering, Sharif University of Technology, Tehran, Iran
  2. 2. Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585, Singapore
  3. 3. Institute of Materials Research and Engineering (IMRE), The Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, #08-03, Innovis, 138634, Singapore
  4. 4. Department of Biotechnology, Alzahra University, Tehran, Iran
  5. 5. Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran
  7. 7. Department of Chamistry, Payame Noor University (PNU), PO Box 19395-3697, Tehran, Iran
  8. 8. Department of Cellular and Molecular Biology, Islamic Azad University, Tehran Medical Branch, Tehran, Iran
  9. 9. Department of Nanobiotechnology, New Technologies Research Group, Pasteur Institute of Iran, Tehran, Iran

Source: Journal of Drug Delivery Science and Technology Published:2020


Abstract

Developing drug delivery systems with both antibacterial and anti-cancer effects is of importance in the treatment process of infection-associated cancers, especially prostate cancer. In this study, Span 60, Tween 60, and cholesterol were used to formulate doxycycline-loaded niosomes as a promising drug carrier system as either antibacterial or anticancer formulation. The formulation process was optimized by multi-objective response surface methodology (RSM), and then characterized. The developed niosomal formulation showed great storage stability for up to 2 weeks. In addition, they showed remarkable drug release in acidic solution (pH = 3) compared with physiological pH (7.4). The in-vitro performances of the as-developed niosomal formulations were investigated for two different applications: antibacterial and anticancer. The antibacterial properties of doxycycline-loaded niosome were investigated using different Gram-negative, and Gram-positive bacteria, where considerable (50–75%) decreases in MIC values were observed. Moreover, the niosomal formulation also possessed promising chemotherapy effects against prostate cancer cells (PC3) but enhanced biocompatibility against normal HEK293 cells. The enhanced chemotherapy effect was correlated to the regulation of different genes as well as changes in cell cycle of PC3 cells after treatment with the niosomal formulation. These carriers could be served as a potential drug delivery system for the treatment of prostate cancer. © 2020 Elsevier B.V.
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