Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! By
Seroepidemiology of Toxoplasma Gondii in Kidney Transplant Patients Publisher



M Latifi MARZIEH ; H Rahban HABIB ; E Pourhosein ELAHE ; Th Tehrani Tannaz HAJIALIREZA ; P Mahjoobi PARISA ; S Dehghani SANAZ
Authors

Source: Caspian Journal of Internal Medicine Published:2025


Abstract

Background: Opportunistic infection after transplantation is a serious problem, with Toxoplasma Gondii (T.gondii) and cytomegalovirus being the most concerning infections. The objective of this research was to examine the seroepidemiology of the T. gondii virus among kidney transplant recipients at Sina Hospital in Tehran from 2017 to 2021. Methods: A total of 342 kidney transplant patients participated in this cross-sectional study using the census method after obtaining consent. Data were collected by reviewing medical records and the transplant database, including demographic characteristics and infectious tests related to kidney transplantation. The collected information was entered into SPSS18 software. Results: The age of the subjects ranged from 10 to 73 years, with 125 patients having kidney failure due to ERDS. The rate of exposure to T. gondii in kidney transplant patients was 54.2%. 125 patients experiencing kidney failure due to ERDS. In kidney transplant patients, the exposure rate to T. gondii was 54.2%. There is a positive correlation between TOX IgG and age (r= 0.12, P = 0.02). There is a positive correlation between CMV IgG and the time elapsed since kidney transplantation (r = 0.11, P = 0.03) and TOX IgG (r = 0.13, p < 0.01). Gender was found not to predict EBV.IgG (β = 0.787, p < 0.21), CMV.IgG (β = 4.752, p < 0.071), TOX.IgG (β = 1.154, p < 0.256) based on regression tests. Conclusion: Physicians should be aware of preventive measures and should consider early diagnosis in cases of compatible symptoms. Screening for anti-Toxoplasma IgM antibodies in potential donors is recommended. © 2025 Elsevier B.V., All rights reserved.
Related Docs
View other Related Docs
1. Frequency of Sero-Positivity in Household Members of the Patients With Positive Toxoplasma Serology; [Frecuencia De Seropositividad En Los Miembros De Hogares De Pacientes Con Serologia Positiva Para Toxoplasma], Revista Espanola de Quimioterapia (2018)
2. Toxoplasma Gondii Infection in Immunocompromised Patients in Iran (2013-2022): A Systematic Review and Meta-Analysis, Iranian Journal of Parasitology (2022)
3. Utility of Blood As the Clinical Specimen for the Diagnosis of Ocular Toxoplasmosis Using Uracil Dna Glycosylase-Supplemented Loop-Mediated Isothermal Amplification and Real-Time Polymerase Chain Reaction Assays Based on Rep-529 Sequence and B1 Gene, BMC Infectious Diseases (2022)
Experts (# of related papers)
View all Related Experts
Hossein Keshavarz Valian (5)
Mahdi Mohebali (4)
Other Related Docs
4. Prevalence of Toxoplasma Gondii Infection in Covid-19 Patients: A Systematic Review and Meta-Analysis, Microbial Pathogenesis (2024)
5. Active Cmv and Ebv Infections in Renal Transplant Recipients With Unexplained Fever and Elevated Serum Creatinine, Renal Failure (2016)
6. Covid-19 Infection in Kidney Transplant Recipients From a Single Center in Iran, Experimental and Clinical Transplantation (2022)
7. Sero-Prevalence of Toxoplasma Gondii Before and During the Covid-19 Pandemic in Northwestern Iran, BMC Infectious Diseases (2024)
8. Global Estimate of Phenotypic and Genotypic Ganciclovir Resistance in Cytomegalovirus Infections Among Hiv and Organ Transplant Patients; a Systematic Review and Meta-Analysis, Microbial Pathogenesis (2020)
9. A Systematic Review and Meta-Analysis of the Prevalence of Toxoplasmosis in Hemodialysis Patients in Iran, Epidemiology and Health (2021)
10. Determining Host Factors Contributing to the Reactivation of Jc Virus in Kidney Transplant Recipients, Virology Journal (2022)
11. Serological and Molecular Survey of Toxoplasma Gondii Infection in Hemodialysis Patients With Chronic Renal Disease in Zahedan, Iran, Journal of Kerman University of Medical Sciences (2021)
12. Hypo-Albuminemia and Perioperative Renal Transplant-Related Infections: A Systematic Review and Meta-Analysis, Urology Journal (2024)
13. Covid-19 Disease in Kidney Transplantation Recipients: A Single- Center Study (Experience of Dr. Shariati Hospital), Journal of Iranian Medical Council (2022)
14. Immunodiagnosis and Molecular Validation of Toxoplasma Gondii Infection Among Patients With End-Stage Renal Disease Undergoing Haemodialysis, Parasitology (2019)
15. Identification and Determination of the Prevalence of Toxoplasma Gondii in Patients With Chronic Renal Failure by Elisa and Pcr, Asian Pacific Journal of Tropical Disease (2016)
16. The Prevalence of Early Toxoplasmosis After Bone Marrow Transplantation Using Pcr: A Study in Iranian Patients, Infectious Disorders - Drug Targets (2022)
17. Frequency and Parasite Load of Toxoplasma Gondii in Hemodialysis Patients Based on Re Gene by Real-Time Pcr, Gene Reports (2021)
18. Comparison of the Toxoplasma Gondii Mice and Cell Culture Derived Antigens in Elisa Assay, Tropical Biomedicine (2017)
19. Seroprevalence of Toxoplasma Gondii Infection in Domestic Dogs in an Area From Northwest of Iran: A Cross-Sectional Study Using Immunodominant Surface Antigen 1 (Sag1), Journal of Parasitic Diseases (2016)
20. Development of High Resolution Melting Analysis As a Diagnostic Tool for Molecular Detection of Toxoplasma Infection in Pregnant Women and Hiv Positive Cases, Iranian Journal of Public Health (2020)