Etiopathogenesis of Psoriasis From Genetic Perspective: An Updated Review Publisher



Babaie F^{1, 2} ; Omraninava M³ ; Gorabi AM⁴ ; Khosrojerdi A⁵ ; Aslani S⁶ ; Yazdchi A⁷ ; Torkamandi S² ; Mikaeili H⁸ ; Sathyapalan T⁹ ; Sahebkar A^{10, 11, 12}
Source: Current Genomics Published:2022

Abstract

Psoriasis is an organ-specific autoimmune disease characterized by the aberrant proliferation and differentiation of keratinocytes, leading to skin lesions. Abnormal immune responses mediated by T cells and dendritic cells and increased production of inflammatory cytokines have been suggested as underlying mechanisms in the pathogenesis of psoriasis. Emerging evidence suggests that there is a heritable basis for psoriatic disorders. Moreover, numerous gene variations have been associated with the disease risk, particularly those in innate and adaptive immune responses and antigen presentation pathways. Herein, this article discusses the genetic implications of psoriatic diseases' etiopathogenesis to develop novel investigative and management options. © 2022 Bentham Science Publishers.