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Etiopathogenesis of Psoriasis From Genetic Perspective: An Updated Review Publisher



Babaie F1, 2 ; Omraninava M3 ; Gorabi AM4 ; Khosrojerdi A5 ; Aslani S6 ; Yazdchi A7 ; Torkamandi S2 ; Mikaeili H8 ; Sathyapalan T9 ; Sahebkar A10, 11, 12
Authors
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Authors Affiliations
  1. 1. Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran
  2. 2. Department of Medical Genetics and Immunology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  3. 3. Department of Infectious Diseases, Faculty of Medical Sciences, Sari Branch, Islamic Azad University, Sari, Iran
  4. 4. Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  6. 6. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Student Research Committee, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  9. 9. Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, United Kingdom
  10. 10. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  11. 11. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  12. 12. Department of Biotechnology, School of Pharmacy, Mashhad University of Western Australia, Mashhad, Iran

Source: Current Genomics Published:2022


Abstract

Psoriasis is an organ-specific autoimmune disease characterized by the aberrant proliferation and differentiation of keratinocytes, leading to skin lesions. Abnormal immune responses mediated by T cells and dendritic cells and increased production of inflammatory cytokines have been suggested as underlying mechanisms in the pathogenesis of psoriasis. Emerging evidence suggests that there is a heritable basis for psoriatic disorders. Moreover, numerous gene variations have been associated with the disease risk, particularly those in innate and adaptive immune responses and antigen presentation pathways. Herein, this article discusses the genetic implications of psoriatic diseases' etiopathogenesis to develop novel investigative and management options. © 2022 Bentham Science Publishers.
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