The Role of Theranostic Nanoparticles in Dental Infectious Diseases: A Review Publisher



M Rostami MITRA ; P Farahani POURIA ; M Karimzadeh MOSLEM ; S Esmaelian SAMAR ; Af Hussein Abbas FADEL ; K Nasiri KAMYAR ; Ha Alrikabi Hareth A ; N Shenasa NAGHMEH
Source: Journal of Drug Delivery Science and Technology Published:2025

Abstract

The mouth cavity is a natural habitat for various microorganisms, many of which serve as a source of resources for pathogenic germs that may lead to systemic, local, oral, and dental diseases. The overuse, overprescription, and excess of antimicrobials lead to the emergence of resistant bacteria. As it is a quick and sensitive diagnosis, efficient and low-toxic therapies are desperately needed. Theranostics, the term for simultaneous diagnosis and treatment, has made nanomaterials indispensable. Nanoparticles (NPs) are being explored in dentistry for their potential to improve the diagnosis, prevention, and treatment of dental infectious illnesses such as periodontitis, peri-implantitis (PIs), and root canal infections. They can enhance antimicrobial activity, improve drug delivery, and enhance the effectiveness of dental materials. Furthermore, developments in nanotechnology have enhanced the sensitivity and quick identification of biomarkers for periodontal and oral disorders. The treatment and diagnosis aspects of dental infectious diseases, including periodontitis, PIs, and root canal infections, are covered in this article. Moreover, research was done on several theranostic NP kinds' therapeutic and diagnostic potential for periodontal and dental illnesses. The study's assessment of the literature demonstrated how advances in nanotheranostics-based diagnosis and treatment are being made to address and lessen the current shortcomings in the widely used techniques for diagnosing and treating infectious dental disorders. © 2025 Elsevier B.V., All rights reserved.