Nanotechnology for Modulating the Periodontal Microenvironment in Surgical Treatment Publisher



Fazel F ; Dehnavi M ; Talari S ; Mohammadikhah M ; Farhadi M ; Sadeghzade A ; Miyanji PK
Source: Nanomedicine Research Journal Published:2025

Abstract

Periodontal disease is a complex inflammatory condition that results in the progressive destruction of periodontal tissues and challenges conventional surgical treatments aimed at tissue regeneration. Recent advances in nanotechnology offer novel strategies to modulate the periodontal microenvironment, enhancing therapeutic precision and efficacy. This review highlights the multifaceted roles of nanomaterials, including nanoparticles, nanofibers, nanoscaffolds, and multifunctional nanocomposites in periodontal therapy. These nanotechnologies facilitate targeted drug delivery, disrupt resilient bacterial biofilms, modulate immune and inflammatory responses, and promote tissue regeneration through biomimetic scaffolding. Additionally, smart nanomaterials with responsive properties enable controlled, site-specific therapeutic actions, minimizing side effects and improving patient outcomes. Despite the promising potential of nanotechnology-enhanced periodontal treatments, challenges such as nanoparticle toxicity, clinical translation, and manufacturing standardization remain. Continued research and rigorous evaluation are essential to establish the safety and efficacy of these innovative approaches. The integration of nanotechnology into periodontal surgical therapy represents a transformative frontier with the potential to significantly improve regenerative outcomes and patient quality of life. © 2025 Elsevier B.V., All rights reserved.