Iranian General Populations' and Health Care Providers' Preferences for Benefits and Harms of Statin Therapy for Primary Prevention of Cardiovascular Disease

Iranian General Populations' and Health Care Providers' Preferences for Benefits and Harms of Statin Therapy for Primary Prevention of Cardiovascular Disease Publisher Pubmed

Saadati H¹ ; Baradaran HR^{1, 2, 3} ; Danaei G⁴ ; Ostovar A⁵ ; Hadaegh F⁶ ; Janani L⁷ ; Steyerberg EW^{8, 9} ; Khalili D^{6, 10}

Show Affiliations

1. Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
2. Ageing Clinical and Experimental Research Team, Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition University of Aberdeen, Aberdeen, United Kingdom
3. Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran
4. Department of Global Health and Population and Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, United States
5. Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
6. Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
7. Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
8. Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands
9. Department of Public Health, Erasmus MC, Rotterdam, Netherlands
10. Department of Biostatistics and Epidemiology, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: BMC Medical Informatics and Decision Making Published:2020

Abstract

Background: The use of statins for primary prevention of cardiovascular diseases is associated with different benefit and harm outcomes. The aime of this study is how important these outcomes are for people and what people's preferences are. Methods: We conducted a preference-eliciting survey incorporating a best–worst scaling (BWS) instrument in Iran from June to November 2019. The relative importance of 13 statins-related outcomes was assessed on a sample of 1085 participants, including 913 general population (486 women) and 172 healthcare providers from the population covered by urban and rural primary health care centers. The participants made trade-off decisions and selected the most and least worrisome outcomes concurrently from 13 choice sets; each contains four outcomes generated using the balanced incomplete block design. Results: According to the mean (SD) BWS scores, which can be (+ 4) in maximum and (− 4) in minimum, in the general population, the most worrisome outcomes were severe stroke (3.37 (0.8)), severe myocardial infarction (2.71(0.7)), and cancer (2.69 (1.33)). While myopathy (− 3. 03 (1.03)), nausea/headache (− 2.69 (0.94)), and treatment discontinuation due to side effects (− 2.24 (1.14)) were the least worrisome outcomes. Preferences were similar between rural and urban areas and among health care providers and the general population with overlapping uncertainty intervals. Conclusion: The rank of health outcomes may be similar in various socio-cultural contexts. The preferences for benefits and harms of statin therapy are essential to assess benefit-harm balance when recommending statins for primary prevention of cardiovascular diseases. © 2020, The Author(s).

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Style	Citing Format
MLA	Saadati H, et al.. "Iranian General Populations' and Health Care Providers' Preferences for Benefits and Harms of Statin Therapy for Primary Prevention of Cardiovascular Disease." BMC Medical Informatics and Decision Making, vol. 20, no. 1, 2020, pp. -.
APA	Saadati H, Baradaran HR, Danaei G, Ostovar A, Hadaegh F, Janani L, Steyerberg EW, Khalili D (2020). Iranian General Populations' and Health Care Providers' Preferences for Benefits and Harms of Statin Therapy for Primary Prevention of Cardiovascular Disease. BMC Medical Informatics and Decision Making, 20(1), -.
Chicago	Saadati H, Baradaran HR, Danaei G, Ostovar A, Hadaegh F, Janani L, Steyerberg EW, Khalili D. "Iranian General Populations' and Health Care Providers' Preferences for Benefits and Harms of Statin Therapy for Primary Prevention of Cardiovascular Disease." BMC Medical Informatics and Decision Making 20, no. 1 (2020): -.
Harvard	Saadati H et al. (2020) 'Iranian General Populations' and Health Care Providers' Preferences for Benefits and Harms of Statin Therapy for Primary Prevention of Cardiovascular Disease', BMC Medical Informatics and Decision Making, 20(1), pp. -.
Vancouver	Saadati H, Baradaran HR, Danaei G, Ostovar A, Hadaegh F, Janani L, et al.. Iranian General Populations' and Health Care Providers' Preferences for Benefits and Harms of Statin Therapy for Primary Prevention of Cardiovascular Disease. BMC Medical Informatics and Decision Making. 2020;20(1):-.
BibTex	@article{ author = {Saadati H and Baradaran HR and Danaei G and Ostovar A and Hadaegh F and Janani L and Steyerberg EW and Khalili D}, title = {Iranian General Populations' and Health Care Providers' Preferences for Benefits and Harms of Statin Therapy for Primary Prevention of Cardiovascular Disease}, journal = {BMC Medical Informatics and Decision Making}, volume = {20}, number = {1}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Saadati H AU - Baradaran HR AU - Danaei G AU - Ostovar A AU - Hadaegh F AU - Janani L AU - Steyerberg EW AU - Khalili D TI - Iranian General Populations' and Health Care Providers' Preferences for Benefits and Harms of Statin Therapy for Primary Prevention of Cardiovascular Disease JO - BMC Medical Informatics and Decision Making VL - 20 IS - 1 SP - EP - PY - 2020 ER -

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