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Effect of Statins on the Plasma/Serum Levels of Inflammatory Markers in Patients With Cardiovascular Disease; a Systematic Review and Meta-Analysis of Randomized Clinical Trials Publisher Pubmed



Abbasifard M1, 2 ; Kandelouei T3 ; Aslani S4 ; Razi B5 ; Imani D6 ; Fasihi M6 ; Cicero FG7 ; Sahebkar A8, 9, 10, 11, 12, 13
Authors
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Authors Affiliations
  1. 1. Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  2. 2. Department of Internal Medicine, School of Medicine, Ali Ibn Abi Talib Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  3. 3. Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, 84112, UT, United States
  4. 4. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Pathobiology and Laboratory Sciences, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
  6. 6. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Enghelab Av., Tehran, 14117, Iran
  7. 7. IRCCS Policlinico S. Orsola-Malpighi, Hypertension and Cardiovascular Risk Factors Research Unit, University of Bologna, Bologna, Italy
  8. 8. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  9. 9. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  10. 10. Department of Biotechnology and Nanotechnology, Faculty of Medicine, The University of Western Australia, Perth, Australia
  11. 11. School of Medicine, The University of Western Australia, Perth, Australia
  12. 12. Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  13. 13. Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, P.O. Box: 91779-48564, Mashhad, Iran

Source: Inflammopharmacology Published:2022


Abstract

Background: The anti-inflammatory properties of statins have been suggested by several researches. However, clinical trials have reported incongruous findings regarding the effect of statins on the levels of inflammatory markers other than high-sensitive C-reactive protein. Therefore, a systematic review and meta-analysis of randomized clinical trials were conducted to illuminate the effect of statins on serum levels of TNF-α, MCP-1, VCAM1, and IL-6 in patients with cardiovascular diseases (CVDs). Methods: To find eligible studies, a systematic literature search of the main databases were conducted up to July 2021. The calculation of the effect sizes was conducted by standardized mean difference (SMD) and 95% confidence intervals (CI). Results: The pooled analyses revealed that statins significantly reduced the TNF-α concentration (SMD = − 0.99 pg/mL; 95% CI − 1.43 to − 0.55 pg/mL; P < 0.001). Regarding dosage, high intensity (SMD = − 0.65 pg/mL; 95% CI − 1.19 to − 0.10, P = 0.02) and moderate/low (SMD = − 1.16 pg/mL; 95% CI − 1.84 to − 0.47, P = 0.001) intensity statins significantly decreased TNF-α levels. Moderate/low intensity statins administration in < 10 weeks treatment duration decreased serum level of TNF-α (SMD = − 0.91 pg/mL; 95% CI − 1.38 to − 0.44, P < 0.001). Lipophilic statins with high intensity dosage significantly decreased level of TNF-α (SMD = − 0.73 pg/mL; 95% CI − 1.43 to − 0.03, P = 0.04). Statins did not change serum levels of MCP-1, VCAM1, and IL-6 in CVD patients. Conclusions: The analyses indicated that statins have beneficial effects in decreasing serum levels of TNF-α in patients with CVDs. © 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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