Study of in Vitro Cytotoxic Performance of Biosynthesized Α-Bi2o3nps, Mn-Doped and Zn-Doped Bi2o3nps Against Mcf-7 and Huvec Cell Lines

Study of in Vitro Cytotoxic Performance of Biosynthesized Α-Bi2o3nps, Mn-Doped and Zn-Doped Bi2o3nps Against Mcf-7 and Huvec Cell Lines Publisher

Sarani M¹ ; Tosan F² ; Hasani SA³ ; Barani M⁴ ; Adelisardou M^{5, 6} ; Khosravani M⁷ ; Niknam S⁸ ; Jadidi Kouhbanani MA⁷ ; Beheshtkhoo N⁷

Show Affiliations

1. Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol, Iran
2. Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran
3. Department of General Surgery, Faculty of Cancer Research Center, University of Medical Shahid Beheshti, Tehran, Iran
4. Medical Mycology and Bacteriology Research Center, Kerman University of Medical Sciences, Kerman, 76169-13555, Iran
5. Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran
6. Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran
7. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
8. Nanoscience and Nanotechnology, University of Kashan, Kashan, Iran

Source: Journal of Materials Research and Technology Published:2022

Abstract

Green-synthesized nanoparticles can be applicable in designing an effective, efficient, and low-risk treatment for cancer. In this regard, we introduced a novel and eco-friendly method for preparing pure α-Bi2O3, Mn-doped Bi2O3, and Zn-doped Bi2O3 nanoparticles with potent cytotoxic activity through the application of Salvadora persica extract as the green reactive, reducing, and capping agent. The biosynthesis and characterization of our product was supported by the results of powder X-ray Powder Diffraction (PXRD), Energy Dispersive X-Ray (EDAX), Field Emission Scanning Electron Microscopy (FESEM), Transmission Electron Microscopy (TEM), Fourier-Transform Infrared (FT-IR), and Raman analysis. The outcomes of SEM analysis displayed the porous morphology of pure α-Bi2O3 nanoparticles, whereas the doping of Zn and Mn turned their structure into a conical shape. The TEM results presented the hexagonal shape of pure α-Bi2O3 NPs with a particle size mean of 46 nm. Additionally, the Zn-doped Bi2O3 nanoparticles consisted spherical particles with 32 nm of size mean, while the Mn-doped Bi2O3 NPs were approximately hexagonal with a particle size mean of 41 nm. The success of doping process was proven by the EDX analysis. Next to their high potential in cytotoxic performance against cancer cell line, the results of MTT assay confirmed the potent cytotoxic activity of synthesized nanoparticles against breast cancer (MCF-7) and human umbilical vein endothelial (HUVEC) cells as well. Considering these observations, these products can be suggested as a proper candidate for biological and medical applications. © 2022 The Author(s).

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Experts (# of related papers)

Mohammad Abdollahi (1)

Style	Citing Format
MLA	Sarani M, et al.. "Study of in Vitro Cytotoxic Performance of Biosynthesized Α-Bi2o3nps, Mn-Doped and Zn-Doped Bi2o3nps Against Mcf-7 and Huvec Cell Lines." Journal of Materials Research and Technology, vol. 19, no. , 2022, pp. 140-150.
APA	Sarani M, Tosan F, Hasani SA, Barani M, Adelisardou M, Khosravani M, Niknam S, Jadidi Kouhbanani MA, Beheshtkhoo N (2022). Study of in Vitro Cytotoxic Performance of Biosynthesized Α-Bi2o3nps, Mn-Doped and Zn-Doped Bi2o3nps Against Mcf-7 and Huvec Cell Lines. Journal of Materials Research and Technology, 19(), 140-150.
Chicago	Sarani M, Tosan F, Hasani SA, Barani M, Adelisardou M, Khosravani M, Niknam S, Jadidi Kouhbanani MA, Beheshtkhoo N. "Study of in Vitro Cytotoxic Performance of Biosynthesized Α-Bi2o3nps, Mn-Doped and Zn-Doped Bi2o3nps Against Mcf-7 and Huvec Cell Lines." Journal of Materials Research and Technology 19, no. (2022): 140-150.
Harvard	Sarani M et al. (2022) 'Study of in Vitro Cytotoxic Performance of Biosynthesized Α-Bi2o3nps, Mn-Doped and Zn-Doped Bi2o3nps Against Mcf-7 and Huvec Cell Lines', Journal of Materials Research and Technology, 19(), pp. 140-150.
Vancouver	Sarani M, Tosan F, Hasani SA, Barani M, Adelisardou M, Khosravani M, et al.. Study of in Vitro Cytotoxic Performance of Biosynthesized Α-Bi2o3nps, Mn-Doped and Zn-Doped Bi2o3nps Against Mcf-7 and Huvec Cell Lines. Journal of Materials Research and Technology. 2022;19():140-150.
BibTex	@article{ author = {Sarani M and Tosan F and Hasani SA and Barani M and Adelisardou M and Khosravani M and Niknam S and Jadidi Kouhbanani MA and Beheshtkhoo N}, title = {Study of in Vitro Cytotoxic Performance of Biosynthesized Α-Bi2o3nps, Mn-Doped and Zn-Doped Bi2o3nps Against Mcf-7 and Huvec Cell Lines}, journal = {Journal of Materials Research and Technology}, volume = {19}, number = {}, pages = {140-150}, year = {2022} }
RIS	TY - JOUR AU - Sarani M AU - Tosan F AU - Hasani SA AU - Barani M AU - Adelisardou M AU - Khosravani M AU - Niknam S AU - Jadidi Kouhbanani MA AU - Beheshtkhoo N TI - Study of in Vitro Cytotoxic Performance of Biosynthesized Α-Bi2o3nps, Mn-Doped and Zn-Doped Bi2o3nps Against Mcf-7 and Huvec Cell Lines JO - Journal of Materials Research and Technology VL - 19 IS - SP - 140 EP - 150 PY - 2022 ER -

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