Alteration in Neuregulin 1/Erbb4 in Absence Epilepsy: Regulatory Effect on Trpv1 Expression

Alteration in Neuregulin 1/Erbb4 in Absence Epilepsy: Regulatory Effect on Trpv1 Expression Publisher

Talebi F^{1, 2} ; Ghorbani S² ; Alizadeh L² ; Akhlaghi F³ ; Moeeni SS⁴ ; Karimzadeh F³

Show Affiliations

1. Immunoregulation Research Center, Shahed University, Tehran, Iran
2. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran
3. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
4. Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Basic and Clinical Neuroscience Published:2022

Abstract

Introduction: The footprint of Neuregulin 1 (NRG1)/ERbB4 in the pathophysiology of some neurological disorders and TRPV1 regulation has been indicated. The alterations in NRG1 and ErbB4 as well as the TRPV1 signaling pathway were investigated during the development of absence epilepsy in the genetic animal model of absence epilepsy. Methods: Male WAG/Rij and Wistar rats were divided into four experimental groups of two and six months of age. The protein levels of NRG1, ERbB4, and TRPV1 were measured in the somatosensory cortex and hippocampus. Results: The cortical protein levels of NRG1 and ErbB4 in the 6-month-old WAG/Rij rats were lower than in Wistar rats. Protein levels of TRPV1 were lower in two- and six-month-old WAG/Rij rats compared to age-matched Wistar rats. Hippocampal protein levels of NRG1 in 6-month-old WAG/Rij rats were lower than two-month-old WAG/Rij rats. Low levels of ErbB4 protein in two-month-old and high levels in six-month-old WAG/Rij rats were found compared to Wistar rats. Protein levels of TRPV1 were lower in the two-month-old and higher in the six-month-old WAG/Rij rats compared to age-matched Wistar rats. Furthermore, a high correlation between NRG1/ERbB4 and TRPV1 expressions in the cortex and hippocampus was indicated. The expression of NRG1/ERbB4 and TRPV1 followed a similar pattern during the life span of Wistar and WAG/Rij rats. Conclusion: Our findings indicated the potential role of the NRG1/ErbB4 pathway as well as TRPV1 in the pathogenesis of absence epilepsy. The regulatory effect of the ERbB4 receptor on the TRPV1 expression has been suggested following the similar pattern of expression. © 2023 Istanbul Tip Fakultesi Dergisi. All rights reserved.

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Style	Citing Format
MLA	Talebi F, et al.. "Alteration in Neuregulin 1/Erbb4 in Absence Epilepsy: Regulatory Effect on Trpv1 Expression." Basic and Clinical Neuroscience, vol. 13, no. 6, 2022, pp. 777-788.
APA	Talebi F, Ghorbani S, Alizadeh L, Akhlaghi F, Moeeni SS, Karimzadeh F (2022). Alteration in Neuregulin 1/Erbb4 in Absence Epilepsy: Regulatory Effect on Trpv1 Expression. Basic and Clinical Neuroscience, 13(6), 777-788.
Chicago	Talebi F, Ghorbani S, Alizadeh L, Akhlaghi F, Moeeni SS, Karimzadeh F. "Alteration in Neuregulin 1/Erbb4 in Absence Epilepsy: Regulatory Effect on Trpv1 Expression." Basic and Clinical Neuroscience 13, no. 6 (2022): 777-788.
Harvard	Talebi F et al. (2022) 'Alteration in Neuregulin 1/Erbb4 in Absence Epilepsy: Regulatory Effect on Trpv1 Expression', Basic and Clinical Neuroscience, 13(6), pp. 777-788.
Vancouver	Talebi F, Ghorbani S, Alizadeh L, Akhlaghi F, Moeeni SS, Karimzadeh F. Alteration in Neuregulin 1/Erbb4 in Absence Epilepsy: Regulatory Effect on Trpv1 Expression. Basic and Clinical Neuroscience. 2022;13(6):777-788.
BibTex	@article{ author = {Talebi F and Ghorbani S and Alizadeh L and Akhlaghi F and Moeeni SS and Karimzadeh F}, title = {Alteration in Neuregulin 1/Erbb4 in Absence Epilepsy: Regulatory Effect on Trpv1 Expression}, journal = {Basic and Clinical Neuroscience}, volume = {13}, number = {6}, pages = {777-788}, year = {2022} }
RIS	TY - JOUR AU - Talebi F AU - Ghorbani S AU - Alizadeh L AU - Akhlaghi F AU - Moeeni SS AU - Karimzadeh F TI - Alteration in Neuregulin 1/Erbb4 in Absence Epilepsy: Regulatory Effect on Trpv1 Expression JO - Basic and Clinical Neuroscience VL - 13 IS - 6 SP - 777 EP - 788 PY - 2022 ER -

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