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Neuregulin1 Gene Variants As a Biomarker for Cognitive Impairments in Patients With Schizophrenia Publisher



Ananloo ES1, 2 ; Yoosefee S3, 4 ; Karimipour M5
Authors
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Authors Affiliations
  1. 1. Department of Psychosomatic, Imam Khomeini Hospital Complex (IKHC), School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  2. 2. Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  3. 3. Neuroscience Research Center, Qom University of Medical Sciences, Qom, Iran
  4. 4. Spiritual Health Research Center, Qom University of Medical Sciences, Qom, Iran
  5. 5. Department of Molecular Medicine, Pasteur Institute of Iran, Tehran, Iran

Source: European Journal of Psychiatry Published:2020


Abstract

Background and objectives: This study aimed to determine whether the selected neuregulin1 (NRG1) gene variants (rs2439272 and rs6988339) are associated with schizophrenia, and Cognitive Impairments Associated with Schizophrenia (CIAS). Methods: Participants with schizophrenia (N = 276) and healthy controls (N = 193) were enrolled. Cognitive assessment using the Wisconsin card sorting test (WCST) and Wechsler adult intelligence scale and genotyping for selected variants of NRG1 were performed. Results: For both the rs2439272 and rs6988339, compared to healthy controls, we found significant higher frequencies of the G allele and the GG genotype in all and male participants with schizophrenia, and with all Wechsler adult intelligence score (WAIS) and Wisconsin card sorting test (WCST) scores (except for non-perseverative score) in all, male and female participants. Conclusions: There was an association between rs2439272, rs6988339 of NRG1 variants and schizophrenia and CIAS (intelligence and executive functions). © 2019 Asociacion Universitaria de Zaragoza para el Progreso de la Psiquiatria y la Salud Mental
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Esmaeil Shahsavand Ananloo (4)
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