Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Relationship Between Preeclampsia Risk and Sencr Rs555172 Gene Polymorphism and Expression Publisher Pubmed



Saravani M1, 2 ; Saeedinia M3 ; Zakidizaji M4 ; Ghasemi M5 ; Rezaei S5 ; Chegini H6 ; Zanganeh R2 ; Kahrizi S6 ; Dana H2 ; Kazemi E7 ; Heidary Z8
Authors
Show Affiliations
Authors Affiliations
  1. 1. Cellular and Molecular Research Center, Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran
  2. 2. Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
  3. 3. Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Human Genetics Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  5. 5. Pregnancy Health Research Center, Department of Obstetrics and Gynecology, Zahedan University of Medical Sciences, Zahedan, Iran
  6. 6. Department of Anatomy and Cognitive Neuroscience, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  7. 7. Department of Obstetrics and Gynecology, Shahid Fayaz-Bakhsh Hospital, Social Security Organization, Tehran, Iran
  8. 8. Vali-e-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Cellular and Molecular Biology Published:2024


Abstract

Preeclampsia, the more severe manifestation of gestational hypertensive disorders, is a major cause of maternal and perinatal morbidity and mortality worldwide. Genetic polymorphisms in long non-coding RNAs (lncRNAs) are considered as potential genetic preeclampsia. This study aimed to explore the association between SENCR rs555172 SNP and PE risk in healthy pregnant women compared to women with preeclampsia. A total of 140 healthy pregnant women and 130 preeclampsia cases were included in the study. The rs555172 genotype was determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and the expression of the SENCR gene was analyzed in 40 placenta tissue samples from both groups. Various statistical approaches were employed to assess the genotypic and allelic frequencies. The results showed no significant difference in the frequency of the rs555172 polymorphism between healthy pregnant women and those with preeclampsia in terms of the dominant (p=0.82), recessive (p=0.39), and over-dominant (p=0.42) models. Additionally, the analysis of SENCR relative expression revealed no significant difference between the two groups (p=0.48). In conclusion, the LncRNA SENCR rs555172(G/A) seems not associated with an increased risk of Preeclampsia in pregnant women. © 2024 Cellular and Molecular Biology Association. All rights reserved.