Association of Mthfr 677C > T and 1298A > C Polymorphisms With Susceptibility to Attention Deficit and Hyperactivity Disorder

Association of Mthfr 677C > T and 1298A > C Polymorphisms With Susceptibility to Attention Deficit and Hyperactivity Disorder Publisher Pubmed

Sadeghiyeh T¹ ; Dastgheib SA² ; Lookzadeh MH³ ; Noorishadkam M³ ; Akbarianbafghi MJ⁴ ; Zareshehneh M⁵ ; Poursharif Z⁶ ; Neamatzadeh H^{5, 7}

Show Affiliations

1. Child and Adolescent Psychiatric Research Center of Additional Behavioral Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2. Department of Medical Genetics, School of Medicine, Shiraz university of Medical Sciences, Shiraz, Iran
3. Department of Pediatrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4. Department of Healthcare Management, Bam University of Medical Sciences, Bam, Iran
5. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
6. Department of Psychology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
7. Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Source: Fetal and Pediatric Pathology Published:2020

Abstract

Background: The associations of MTHFR polymorphisms with risk of attention deficit and hyperactivity disorder (ADHD) are poorly elucidated. This study was performed to evaluate the association of MTHFR polymorphisms with ADHD risk in Iranian children. Methods: This case–control study included 214 children with ADHD and 220 healthy subjects. The MTHFR 677C > T and 1298A > C polymorphisms were genotyped by an ABI PRISMs 7500 real-time PCR System. The odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association. Results: The MTHFR 1298A > C polymorphism CC genotype (OR= 1.526, 95% CI 1.004–2.320, p = 0.048) and C allele (OR= 1.336, 95% CI 0.1023–1.745, p = 0.034) were associated with an increased risk of ADHD. There was no significant association between MTHFR 677C > T polymorphism and increased risk of ADHD. Conclusions: Our results revealed that the MTHFR 1298A > C polymorphism but not the MTHFR 677 C > T is associated with increased risk of ADHD in Iranian children. © 2019 Taylor & Francis Group, LLC.

2. Association Between Mthfr Gene Polymorphism and Susceptibility to Autism Spectrum Disorders: Systematic Review and Meta-Analysis, Research in Autism Spectrum Disorders (2020)

Style	Citing Format
MLA	Sadeghiyeh T, et al.. "Association of Mthfr 677C > T and 1298A > C Polymorphisms With Susceptibility to Attention Deficit and Hyperactivity Disorder." Fetal and Pediatric Pathology, vol. 39, no. 5, 2020, pp. 422-429.
APA	Sadeghiyeh T, Dastgheib SA, Lookzadeh MH, Noorishadkam M, Akbarianbafghi MJ, Zareshehneh M, Poursharif Z, Neamatzadeh H (2020). Association of Mthfr 677C > T and 1298A > C Polymorphisms With Susceptibility to Attention Deficit and Hyperactivity Disorder. Fetal and Pediatric Pathology, 39(5), 422-429.
Chicago	Sadeghiyeh T, Dastgheib SA, Lookzadeh MH, Noorishadkam M, Akbarianbafghi MJ, Zareshehneh M, Poursharif Z, Neamatzadeh H. "Association of Mthfr 677C > T and 1298A > C Polymorphisms With Susceptibility to Attention Deficit and Hyperactivity Disorder." Fetal and Pediatric Pathology 39, no. 5 (2020): 422-429.
Harvard	Sadeghiyeh T et al. (2020) 'Association of Mthfr 677C > T and 1298A > C Polymorphisms With Susceptibility to Attention Deficit and Hyperactivity Disorder', Fetal and Pediatric Pathology, 39(5), pp. 422-429.
Vancouver	Sadeghiyeh T, Dastgheib SA, Lookzadeh MH, Noorishadkam M, Akbarianbafghi MJ, Zareshehneh M, et al.. Association of Mthfr 677C > T and 1298A > C Polymorphisms With Susceptibility to Attention Deficit and Hyperactivity Disorder. Fetal and Pediatric Pathology. 2020;39(5):422-429.
BibTex	@article{ author = {Sadeghiyeh T and Dastgheib SA and Lookzadeh MH and Noorishadkam M and Akbarianbafghi MJ and Zareshehneh M and Poursharif Z and Neamatzadeh H}, title = {Association of Mthfr 677C > T and 1298A > C Polymorphisms With Susceptibility to Attention Deficit and Hyperactivity Disorder}, journal = {Fetal and Pediatric Pathology}, volume = {39}, number = {5}, pages = {422-429}, year = {2020} }
RIS	TY - JOUR AU - Sadeghiyeh T AU - Dastgheib SA AU - Lookzadeh MH AU - Noorishadkam M AU - Akbarianbafghi MJ AU - Zareshehneh M AU - Poursharif Z AU - Neamatzadeh H TI - Association of Mthfr 677C > T and 1298A > C Polymorphisms With Susceptibility to Attention Deficit and Hyperactivity Disorder JO - Fetal and Pediatric Pathology VL - 39 IS - 5 SP - 422 EP - 429 PY - 2020 ER -

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