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Association of Mthfr 677C>T and 1298A>C Polymorphisms With Susceptibility to Autism: A Systematic Review and Meta-Analysis Publisher Pubmed



Sadeghiyeh T1 ; Dastgheib SA2 ; Mirzaeekhoramabadi K3 ; Morovatisharifabad M4 ; Akbarianbafghi MJ5 ; Poursharif Z6 ; Mirjalili SR7 ; Neamatzadeh H8, 9
Authors
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Authors Affiliations
  1. 1. Child and Adolescent Psychiatric Research Center of Addiction and Behavioral Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  2. 2. Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
  4. 4. Department of Basic Science, Faculty of Veterinary Medicine, Ardakan University, Ardakan, Iran
  5. 5. Department of Health Care Management, Bam University of Medical Sciences, Bam, Iran
  6. 6. Department of Psychiatry, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Pediatrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  8. 8. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  9. 9. Mother and Newborn Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Source: Asian Journal of Psychiatry Published:2019


Abstract

Several studies have investigated association of MTHFR 677C > T and 1298A > C polymorphisms with risk of autism, but they have reported controversial and inconclusive results. The present meta-analysis was designed to evaluate association of MTHFR 677C > T and 1298A > C polymorphisms with risk of autism. A comprehensive literature search was done in PubMed, EMBASE, and CNKI databases to identify all eligible publications up to April 01, 2019. Finally, 25 case-control studies including 18 studies on MTHFR 677C > T and 7 studies on MTHFR 1298A > C polymorphism were selected. Overall, a significant association was found between MTHFR 677C > T and an increased risk of autism under all five genetic models (T vs. C: OR = 1.483, 95% CI 1.188–1.850, p ≤ 0.001; TT vs. CC: OR = 1.834, 95% CI 1.155–2.913, p = 0.010; TC vs. CC: OR = 1.512, 95% CI 1.101–2.078, p = 0.011; TT + TC vs. CC: OR = 1.632, 95% CI 1.261–2.113, p ≤ 0.001; and TT vs. TC + CC: OR = 1.427, 95% CI 1.002–2.032, p = 0.049). However, no significant association was found between MTHFR 1298A > C and autism risk. Stratified analyses showed that MTHFR 677C > T and 1298A > C polymorphisms are involved in genetic susceptibility of autism by ethnicity. Results of this meta-analysis indicated that MTHFR 677C > T polymorphism may be associated with increased risk of autism in overall and by ethnicity, while MTHFR 1298A > C was reported to be significantly associated with the risk of autism only in Caucasians. MTHFR polymorphisms could be used as a diagnostic marker for autism with respect to ethnicity background. © 2019 Elsevier B.V.
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