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The Effects of Green Cardamom Supplementation on Blood Glucose, Lipids Profile, Oxidative Stress, Sirtuin-1 and Irisin in Type 2 Diabetic Patients: A Study Protocol for a Randomized Placebo-Controlled Clinical Trial Publisher Pubmed



Aghasi M1 ; Ghazizahedi S1 ; Koohdani F2 ; Siassi F1 ; Nasliesfahani E3 ; Keshavarz A4 ; Qorbani M5 ; Khoshamal H1 ; Salarimoghaddam A1 ; Sotoudeh G1
Authors
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Authors Affiliations
  1. 1. Tehran University of Medical Sciences, Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran, Iran
  2. 2. Tehran University of Medical Sciences, Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran, Iran
  3. 3. Tehran University of Medical Sciences, Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran, Iran
  4. 4. Tehran University of Medical Sciences, Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran, Iran
  5. 5. Alborz University of Medical Sciences, Department of Community Medicine, School of Medicine, Karaj, Iran

Source: BMC Complementary and Alternative Medicine Published:2018


Abstract

Background: It has been suggested that the antioxidant, anti-inflammatory and hypolipidemic activities of cardamom may improve diabetes. However, the effect of this spice has not been investigated in diabetic subjects. This study was planned to determine the effects of green cardamom on blood glucose, lipids and oxidative stress status in type 2 diabetic patients. Methods/design: Eighty overweight or obese patients with type 2 diabetes will be selected. They will be randomly assigned to receive 3g/d green cardamom or placebo for 10weeks. The socio demographic, physical activity and 24-h food recall questionnaires will be collected for each subject. Weight, height and waist circumference will be measured. Determination of blood glucose, lipid profile, and oxidative stress biomarkers including serum levels of total antioxidant capacity (TAC), malondialdehyde (MDA), and glutathione peroxidase (GPx) and superoxide dismutase (SOD) in red blood cells will be performed. The homeostasis model assessment-estimated insulin resistance (HOMA-IR) index and the quantitative insulin-sensitivity check index (QUICKI) will be calculated. Also, serum levels of irisin, and Sirtuin1 (SIRT1) will be measured. Discussion: This trial will be the first study to explore the effects of green cardamom supplementation on glycemic control, lipid profile and oxidative stress in patients with type 2 diabetes mellitus. The results from this trial will provide evidence on the efficacy of green cardamom in type 2 diabetes mellitus. © 2018 The Author(s).
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