Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effects of Green Cardamom Supplementation on Serum Levels of Hs-Crp, Dimethylarginine, Nitric Oxide and Blood Pressure in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo Controlled, Clinical Trial Publisher



Zahedi SG1, 4 ; Koohdani F2, 4 ; Qorbani M3, 4 ; Nasliesfahani E4, 5 ; Aghasi M1, 4 ; Khoshamal H1, 4 ; Keshavarz A4 ; Sotoudeh G1, 4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  4. 4. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Herbal Medicine Published:2022


Abstract

Purpose: Cardamom contains phytochemicals with a potential role in lowering blood pressure (BP) and improving the inflammatory status in type 2 diabetes mellitus (T2DM). However, only a few studies have been carried out to evaluate the effect of cardamom in these patients. Therefore, the aim of this study was to assess the effects of green cardamom supplementation on serum high-sensitivity C–reactive protein (hs-CRP), asymmetric dimethylarginine (ADMA), nitric oxide (NO), systolic blood pressure (SBP) and diastolic blood pressure (DBP) in patients with T2DM. Materials and Methods: In this double blind, randomized, controlled clinical trial, 83 patients with T2DM were divided randomly into two groups, including the green cardamom group (3 g/d, n = 41) and placebo group (3 g/d, n = 42). All patients received the supplements for 10 weeks. Serum levels of hs-CRP, ADMA, NO, SBP and DBP were measured at baseline and week 10. Results: The intention-to-treat (ITT) analysis showed a decrease in mean serum hs-CRP levels [from 5.22 (3.56) to 4.81 ng/ml (3.72); p < 0.05] along with a significant increase in mean serum NO levels [from 65.6 (22.6) to 84 Mµ (26.3)], (p < 0.001). There was a significant decrease in mean SBP in the cardamom group [from 125.2 (12.4) to 119.4 mm/hg (11.8)] compared to the placebo group [128.1 (15.6) to 126.7 mmHg (13.5)] (p < 0.001). Furthermore, ITT analysis showed a decrease in mean SBP [from 125.6 (12.2) to 120 mmHg (11.59)] (p < 0.001). Changes in serum ADMA and DBP levels were not statistically significant between the two groups. In addition, in Per-Protocol (PP) analysis, a significant decrease was found in mean serum hs-CRP levels in the cardamom group [from 5.25 (3.66) to 4.87 ng/ml (3.8)] compared to the placebo group [4.4 (3) to 5.7 ng/ml (4.2)]; (p < 0.05), along with a significant increase in mean serum NO levels in the cardamom group [from 62.9 (18) to 82.5 Mµ (24.6)] compared to the placebo group [70.7 (28) to 72.1 Mµ (25.8)]; (p < 0.001). Conclusion: Green cardamom may have beneficial effects on SBP, NO and hs-CRP levels in patients with T2DM. Improvement in BP and inflammatory markers can help prevent the complications from T2DM including cardiovascular risk in these patients. © 2022
Related Docs
View other Related Docs
1. The Effects of Green Cardamom Supplementation on Blood Pressure and Endothelium Function in Type 2 Diabetic Patients a Study Protocol for a Randomized Controlled Clinical Trial, Medicine (United States) (2020)
2. The Effects of Elettaria Cardamom Supplementation on Inflammatory Markers and Vascular Function in Patients With Type 2 Diabetes Mellitus: A Mechanism -Based Randomized Clinical Trial, Journal of Herbal Medicine (2021)
3. Green Cardamom Increases Sirtuin-1 and Reduces Inflammation in Overweight or Obese Patients With Non-Alcoholic Fatty Liver Disease: A Double-Blind Randomized Placebo-Controlled Clinical Trial, Nutrition and Metabolism (2018)
4. The Effects of Green Cardamom on Blood Glucose Indices, Lipids, Inflammatory Factors, Paraxonase-1, Sirtuin-1, and Irisin in Patients With Nonalcoholic Fatty Liver Disease and Obesity: Study Protocol for a Randomized Controlled Trial, Trials (2017)
5. The Effects of Green Cardamom Supplementation on Blood Glucose, Lipids Profile, Oxidative Stress, Sirtuin-1 and Irisin in Type 2 Diabetic Patients: A Study Protocol for a Randomized Placebo-Controlled Clinical Trial, BMC Complementary and Alternative Medicine (2018)
6. Green Cardamom Supplementation Improves Serum Irisin, Glucose Indices, and Lipid Profiles in Overweight or Obese Non-Alcoholic Fatty Liver Disease Patients: A Double-Blind Randomized Placebo-Controlled Clinical Trial, BMC Complementary and Alternative Medicine (2019)
7. Effects of Cardamom Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials, Phytotherapy Research (2020)
8. Saffron Supplementation Effects on Glycemic Indices: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials, International Journal of Food Properties (2020)
Experts (# of related papers)
View all Related Experts
Ensieh Nasli Esfahani (3)
Seyed Fatemeh Yaghoubi (1)
Other Related Docs
9. A Glance at the Therapeutic Potential of Irisin Against Diseases Involving Inflammation, Oxidative Stress, and Apoptosis: An Introductory Review, Pharmacological Research (2018)
10. Cardamom Supplementation Improves Inflammatory and Oxidative Stress Biomarkers in Hyperlipidemic, Overweight, and Obese Pre-Diabetic Women: A Randomized Double-Blind Clinical Trial, Journal of the Science of Food and Agriculture (2017)
11. The Effects of Saffron Supplementation on Cardiovascular Risk Factors in Adults: A Systematic Review and Dose-Response Meta-Analysis, Frontiers in Nutrition (2022)
12. Beneficial Effects of Green Cardamom on Serum Sirt1, Glycemic Indices and Triglyceride Levels in Patients With Type 2 Diabetes Mellitus: A Randomized Double-Blind Placebo Controlled Clinical Trial, Journal of the Science of Food and Agriculture (2019)