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A Comparison of Pediatric and Adult Neuromyelitis Optica Spectrum Disorders: A Review of Clinical Manifestation, Diagnosis, and Treatment Publisher Pubmed



Baghbanian SM1 ; Asgari N2 ; Sahraian MA3 ; Moghadasi AN3
Authors
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Authors Affiliations
  1. 1. Neurology Department, Mazandaran University of Medical Science, Booalisina Hospital, Pasdaran Boulevard, Sari, Iran
  2. 2. Owens-gruppen Naestved/Slagelse/Ringsted Sygehuse, Region Sjaelland J.B. Winslows Vej 9, indgang B, 1. Sal 5000, Odense C, Denmark
  3. 3. MS Research Centre, Department of Neurology, Tehran University of Medical Sciences, Neuroscience Institute, Sina Hospital, Hasan Abad Square, Tehran, 11367-46911, Iran

Source: Journal of the Neurological Sciences Published:2018


Abstract

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disorder of the central nervous system (CNS). Serum immunoglobulin G autoantibodies (NMO-IgG) are identified in the majority of NMOSD patients. The Pediatric form presents before 18 years. Based on the similarity of clinical, neuroimaging, and laboratory characteristics of pediatric NMOSD to those of the adult form, the international panel suggested that adult criteria of NMOSD also are appropriate in pediatric patients. However, the proposed criteria need validation in pediatric patients. This strategy poses challenges to the study design in clinical trials in pediatric NMOSD patients. © 2018
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