Partners in Crime: Autoantibodies Complicit in Covid-19 Pathogenesis

Partners in Crime: Autoantibodies Complicit in Covid-19 Pathogenesis Publisher Pubmed

Taghadosi M¹ ; Safarzadeh E² ; Asgarzadeh A³ ; Roghani SA^{4, 5} ; Shamsi A¹ ; Jalili C⁶ ; Assar S⁵ ; Soufivand P⁵ ; Pournazari M⁵ ; Feizollahi P¹ ; Nicknam MH^{7, 8} ; Asghariazar V⁹ ; Vaziri S¹⁰ ; Shahriari H¹¹ Show All Authors

Taghadosi M¹
Safarzadeh E²
Asgarzadeh A³
Roghani SA^{4, 5}
Shamsi A¹
Jalili C⁶
Assar S⁵
Soufivand P⁵
Pournazari M⁵
Feizollahi P¹
Nicknam MH^{7, 8}
Asghariazar V⁹
Vaziri S¹⁰
Shahriari H¹¹
Mohammadi A¹²

Show Affiliations

1. Immunology Department, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
2. Department of Microbiology, Parasitology, and Immunology, Ardabil University of Medical Sciences, Ardabil, Iran
3. Students Research Committee, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
4. Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
5. Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
6. Department of Anatomy, Kermanshah University of Medical Sciences, Kermanshah, Iran
7. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
8. Molecular Immunology Research Centre, Tehran University of Medical Sciences, Tehran, Iran
9. Deputy of Research and Technology, Ardabil University of Medical Sciences, Ardabil, Iran
10. Infectious Disease Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
11. Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
12. Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran

Source: Reviews in Medical Virology Published:2023

Abstract

Autoantibodies (AABs) play a critical role in the pathogenesis of autoimmune diseases (AIDs) and serve as a diagnostic and prognostic tool in assessing these complex disorders. Viral infections have long been recognized as a principal environmental factor affecting the production of AABs and the development of autoimmunity. COVID-19 has primarily been considered a hyperinflammatory syndrome triggered by a cytokine storm. In the following, the role of maladaptive B cell response and AABs became more apparent in COVID-19 pathogenesis. The current review will primarily focus on the role of extrafollicular B cell response, Toll-like receptor-7 (TLR-7) activation, and neutrophil extracellular traps (NETs) formation in the development of AABs following SARS-CoV-2 infection. In the following, this review will clarify how these AABs dysregulate immune response to SARS-CoV-2 by disrupting cytokine function and triggering neutrophil hyper-reactivity. Finally, the pathologic effects of these AABs will be further described in COVID-19 associate clinical manifestations, including venous and arterial thrombosis, a multisystem inflammatory syndrome in children (MIS-C), acute respiratory distress syndrome (ARDS), and recently described post-acute sequelae of COVID-19 (PASC) or long-COVID. © 2022 John Wiley & Sons Ltd.

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Style	Citing Format
MLA	Taghadosi M, et al.. "Partners in Crime: Autoantibodies Complicit in Covid-19 Pathogenesis." Reviews in Medical Virology, vol. 33, no. 2, 2023, pp. -.
APA	Taghadosi M, Safarzadeh E, Asgarzadeh A, Roghani SA, Shamsi A, Jalili C, Assar S, Soufivand P, Pournazari M, Feizollahi P, Nicknam MH, Asghariazar V, Vaziri S, Shahriari H, Mohammadi A (2023). Partners in Crime: Autoantibodies Complicit in Covid-19 Pathogenesis. Reviews in Medical Virology, 33(2), -.
Chicago	Taghadosi M, Safarzadeh E, Asgarzadeh A, Roghani SA, Shamsi A, Jalili C, Assar S, et al.. "Partners in Crime: Autoantibodies Complicit in Covid-19 Pathogenesis." Reviews in Medical Virology 33, no. 2 (2023): -.
Harvard	Taghadosi M et al. (2023) 'Partners in Crime: Autoantibodies Complicit in Covid-19 Pathogenesis', Reviews in Medical Virology, 33(2), pp. -.
Vancouver	Taghadosi M, Safarzadeh E, Asgarzadeh A, Roghani SA, Shamsi A, Jalili C, et al.. Partners in Crime: Autoantibodies Complicit in Covid-19 Pathogenesis. Reviews in Medical Virology. 2023;33(2):-.
BibTex	@article{ author = {Taghadosi M and Safarzadeh E and Asgarzadeh A and Roghani SA and Shamsi A and Jalili C and Assar S and Soufivand P and Pournazari M and Feizollahi P and Nicknam MH and Asghariazar V and Vaziri S and Shahriari H and Mohammadi A}, title = {Partners in Crime: Autoantibodies Complicit in Covid-19 Pathogenesis}, journal = {Reviews in Medical Virology}, volume = {33}, number = {2}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Taghadosi M AU - Safarzadeh E AU - Asgarzadeh A AU - Roghani SA AU - Shamsi A AU - Jalili C AU - Assar S AU - Soufivand P AU - Pournazari M AU - Feizollahi P AU - Nicknam MH AU - Asghariazar V AU - Vaziri S AU - Shahriari H AU - Mohammadi A TI - Partners in Crime: Autoantibodies Complicit in Covid-19 Pathogenesis JO - Reviews in Medical Virology VL - 33 IS - 2 SP - EP - PY - 2023 ER -

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