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Are There Atypical Leishmania Species Responsible for the Kala-Azar Persistence in Northeast Iran? Publisher Pubmed



Shafiei R1 ; Azimian A2 ; Mohebali M3 ; Badiei Z4 ; Firouzeh N1 ; Raeghi S5
Authors
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Authors Affiliations
  1. 1. Vector-borne Diseases Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
  2. 2. Department of Pathology and Laboratory Sciences, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
  3. 3. Center for Research of Endemic Parasites of Iran, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pediatrics, School of Medicine, Sheikh Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. Department of Parasitology & Mycology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Source: Acta Parasitologica Published:2025


Abstract

Porpuse: Human visceral leishmaniasis (HVL) is a severe form of leishmaniasis caused by protozoan parasites of the genus Leishmania. Methods: From 2013 to 2022, this study, molecular diagnosis was conducted on 50 pediatric bone marrow aspiration samples from northeast Iran, all of which had previously been confirmed to have visceral leishmaniasis. The ITS-rDNA gene and phylogenetic analysis were performed. Results: The results revealed that 49 samples tested positive for L. infantum species, whereas 1 sample was identified as L. major. All three L. infantum isolates showed similar haplotypes, whereas the L. major isolate exhibited nucleotide differences in the sequence analyzed. Conclusion: It could be concluded that visceral manifestations of cutaneous leishmaniasis in children living in endemic areas should be considered a contributing factor to the development of HVL. The present study provides a relatively comprehensive snapshot of unusual leishmania species status that could be responsible for HVL development. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2025.
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