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Prevalence and Phylogenic Study of Human T-Lymphotropic Virus 1 in Patients With Thalassemia in the Northeast of Iran Publisher



Abedi F1, 2 ; Mozhgani SH3 ; Rahimzadegan M2 ; Gudarzi H3 ; Valizadeh N4 ; Rezaee SA4
Authors
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Authors Affiliations
  1. 1. Department of Infectious Disease, Birjand University of Medical Sciences, Birjand, Iran
  2. 2. Department of Infectious Disease, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Immunology Research Center, Inflammation and Inflammatory Diseases Division, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Future Virology Published:2017


Abstract

Aim: This study aimed to investigate the frequency and phylogenetic distribution of human T-lymphotropic virus type 1 (HTLV-1) in thalassemia cases. Methods: Between 2006 and 2013, a total of 100 thalassemic individuals were investigated for HTLV-1 infections. Results: Four people (4%) were reactive for HTLV antibodies. No considerable correlation was seen between factors such as age, blood transfusion history, surgery, marital status, gender and blood types. All HTLV-1 sequences belonged to the transcontinental (A) subgroup in the cosmopolitan (a) subtype. Conclusion: In addition to phylogenetic distribution, our results demonstrate that the prevalence of HTLV-1 infection among thalassemia patients in Mashhad is higher than that of previous studies. © 2017 Future Medicine Ltd.
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