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Levels of Mania and Cognitive Performance Two Years After Ect in Patients With Bipolar I Disorder - Results From a Follow-Up Study Publisher Pubmed



Haghighi M1 ; Barikani R1 ; Jahangard L1 ; Ahmadpanah M1 ; Bajoghli H2 ; Sadeghi Bahmani D3 ; Holsboertrachsler E3 ; Brand S3, 4
Authors
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Authors Affiliations
  1. 1. Research Center for Behavioral Disorders and Substance Abuse, Hamadan University of Medial Sciences, Hamadan, Iran
  2. 2. Iranian National Center for Addiction Studies (INCAS), Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medial Sciences, Tehran, Iran
  3. 3. Psychiatric Clinics of the University of Basel, Center for Affective, Stress and Sleep Disorders, University of Basel, Wilhelm Klein-Strasse 27, Basel, 4012, Switzerland
  4. 4. Department of Sport, Exercise, and Health, University of Basel, Basel, Switzerland

Source: Comprehensive Psychiatry Published:2016


Abstract

Background There is limited evidence on the long-term outcomes for patients with bipolar I disorder (BP-I-D) and treated with ECT. Therefore, we asked whether mania scores and cognitive performance at the end of ECT treatment (baseline/BL) predicted mania scores, cognitive performance, recurrence, treatment adherence, and mood (depression; hypomania) two years later (follow-up/FU). Method 38 patients with BP-I-D undergoing ECT at baseline were followed up two years later. A brief psychiatric and cognitive assessment (Mini Mental State Examination; short-term verbal memory test) was performed; patients completed questionnaires covering recurrence, treatment adherence, and mood (depression; hypomania). Results High cognitive performance at BL predicted high cognitive performance at FU; low mania scores at BL predicted low mania scores at FU. By FU, cognitive performance had increased and mania scores decreased. Mania scores and cognitive performance at BL did not predict recurrence, or adherence to medication, or mood (depression; hypomania). Conclusions The pattern of results suggests that after two years of successful treatment of acute mania with ECT, cognitive impairment, measured by MMSE and a short-term verbal memory test, is not impaired and mood symptom recurrence seems to be improved. Mania scores and cognitive performance at the end of ECT treatment predicted neither mood (depression; hypomania), nor recurrence, or adherence to medication two years later. © 2016 Elsevier Inc.
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