Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effect of Adjunctive Celecoxib on Bdnf in Manic Patients Undergoing Electroconvulsive Therapy: A Randomized Double Blind Controlled Trial Publisher Pubmed



Kargar M1 ; Yoosefi A2 ; Akhondzadeh S3 ; Artonian V4 ; Ashouri A5 ; Ghaeli P6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Amiralam Hospital, Department of Anesthesiology, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Psychiatry, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. School of Public Health, Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Faculty of Pharmacy and Psychiatry, Psychology Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Pharmacopsychiatry Published:2015


Abstract

Introduction: The possible effect of inflammatory factors on decreasing BDNF has been proposed in the literature. There is conflicting evidence regarding association between BDNF level alteration and treatment response in depressive patients undergoing electroconvulsive therapy (ECT). This study investigated the effects of celecoxib in manic patients undergoing ECT on treatment response and BDNF levels. Methods: This randomized, double-blind, clinical trial included 35 manic patients who received either celecoxib (200 mg twice daily) or placebo, from one day before the 1st ECT session throughout the 6th session. BDNF levels were measured at baseline, 1st, 3rd and 6th ECT sessions. Young mania rating scale was used to assess treatment response. Results: Adding celecoxib was not associated with a significant rise in BDNF levels following ECT. No difference was noted between groups in terms of treatment response. No significant association was found between changes in BDNF levels and patients' responses. Discussion: Adjuvant celecoxib did not significantly affect the BDNF level or the treatment response following ECT in manic patients. © 2015 Georg Thieme Verlag KG Stuttgart. New York.
Related Docs
View other Related Docs
1. Celecoxib Adjunctive Therapy for Acute Bipolar Mania: A Randomized, Double-Blind, Placebo-Controlled Trial, Bipolar Disorders (2015)
2. Celecoxib Versus Diclofenac in Mild to Moderate Depression Management Among Breast Cancer Patients: A Double-Blind, Placebo-Controlled, Randomized Trial, Annals of Pharmacotherapy (2015)
3. Efficacy and Safety of Celecoxib Monotherapy for Mild to Moderate Depression in Patients With Colorectal Cancer: A Randomized Double-Blind, Placebo Controlled Trial, Psychiatry Research (2017)
4. A Randomized, Double-Blind Placebo-Controlled Trial on Effectiveness and Safety of Celecoxib Adjunctive Therapy in Adolescents With Acute Bipolar Mania, Journal of Child and Adolescent Psychopharmacology (2017)
5. Celecoxib for the Treatment of Mild-To-Moderate Depression Due to Acute Brucellosis: A Double-Blind, Placebo-Controlled, Randomized Trial, Journal of Clinical Pharmacy and Therapeutics (2015)
6. Chronic Rem Sleep Deprivation Leads to Manic- and Ocd-Related Behaviors, and Decreases Hippocampal Bdnf Expression in Female Rats, Psychopharmacology (2024)
7. Possible Involvement of Nitric Oxide in Antidepressant-Like Effect of Silymarin in Male Mice, Pharmaceutical Biology (2015)
8. Electroconvulsive Therapy (Ect) and Aerobic Exercise Training (Aet) Increased Plasma Bdnf and Ameliorated Depressive Symptoms in Patients Suffering From Major Depressive Disorder, Journal of Psychiatric Research (2016)
Experts (# of related papers)
View all Related Experts
Shahin Akhondzadeh Basti (14)
Ladan Kashani (3)
Other Related Docs
9. Celecoxib As an Adjuvant to Fluvoxamine in Moderate to Severe Obsessive-Compulsive Disorder: A Double-Blind, Placebo-Controlled, Randomized Trial, Pharmacopsychiatry (2015)
10. Efficacy and Safety of Celecoxib for Treatment of Mild to Moderate Postpartum Depression: A Randomized, Double-Blind, Placebo-Controlled Trial, Archives of Gynecology and Obstetrics (2024)
11. Therapeutic Effects of Minocycline on Mild-To-Moderate Depression in Hiv Patients: A Double-Blind, Placebo-Controlled, Randomized Trial, International Clinical Psychopharmacology (2016)
12. The Effects of Pioglitazone Adjuvant Therapy on Negative Symptoms of Patients With Chronic Schizophrenia: A Double-Blind and Placebo-Controlled Trial, Human Psychopharmacology (2016)
13. Craving and Drug Reward: A Comparison of Celecoxib and Ibuprofen in Detoxifying Opiate Addicts, Iranian Journal of Psychiatry (2017)
14. Effect of Alcohol on Brain-Derived Neurotrophic Factor (Bdnf) Blood Levels: A Systematic Review and Meta-Analysis, Scientific Reports (2023)
15. The Role of Neurotrophic Factors in Pathophysiology of Major Depressive Disorder, Advances in Experimental Medicine and Biology (2021)
16. Efficacy and Safety of Pentoxifylline Combination Therapy in Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, International Clinical Psychopharmacology (2021)
17. Acetaminophen As Adjuvant to Risperidone in Chronic Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Iranian Journal of Psychiatry (2018)
18. The Effect of Psychedelics on the Level of Brain-Derived Neurotrophic Factor: A Systematic Review and Meta-Analysis, Journal of Psychopharmacology (2024)
19. Simvastatin As an Adjuvant Therapy to Fluoxetine in Patients With Moderate to Severe Major Depression: A Double-Blind Placebo-Controlled Trial, Journal of Psychopharmacology (2015)
20. Celecoxib in Treatment of Postpartum Depression: A Case Report, Archives of Iranian Medicine (2023)
21. Depression and Inflammation: Is There Any Role for Biomarkers?, Avicenna Journal of Medical Biotechnology (2019)