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Cerebellar Microstructural Abnormalities in Obsessive–Compulsive Disorder (Ocd): A Systematic Review of Diffusion Tensor Imaging Studies Publisher Pubmed



Shobeiri P1, 2, 3 ; Hosseini Shabanan S4 ; Haghshomar M2, 5 ; Khanmohammadi S1, 3 ; Fazeli S4 ; Sotoudeh H6 ; Kamali A7
Authors
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Authors Affiliations
  1. 1. Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. NeuroImaging Network (NIN), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  3. 3. Non–Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Radiology, University of California San Diego, San Diego, CA, United States
  5. 5. Department of Radiology, Northwestern University, Chicago, IL, United States
  6. 6. Department of Radiology and Neurology, University of Alabama at Birmingham (UAB), Birmingham, AL, United States
  7. 7. Department of Diagnostic and Interventional Radiology, University of Texas McGovern Medical School, Houston, TX, United States

Source: Cerebellum Published:2024


Abstract

Previous neuroimaging studies have suggested that obsessive–compulsive disorder (OCD) is associated with altered resting-state functional connectivity of the cerebellum. In this study, we aimed to describe the most significant and reproducible microstructural abnormalities and cerebellar changes associated with obsessive–compulsive disorder (OCD) using diffusion tensor imaging (DTI) investigations. PubMed and EMBASE were searched for relevant studies using the PRISMA 2020 protocol. A total of 17 publications were chosen for data synthesis after screening titles and abstracts, full-text examination, and executing the inclusion criteria. The patterns of cerebellar white matter (WM) integrity loss, determined by fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) metrics, varied across studies and symptoms. Changes in fractional anisotropy (FA) values were described in six publications, which were decreased in four and increased in two studies. An increase in diffusivity parameters of the cerebellum (i.e., MD, RD, and AD) in OCD patients was reported in four studies. Alterations of the cerebellar connectivity with other brain areas were also detected in three studies. Heterogenous results were found in studies that investigated cerebellar microstructural abnormalities in correlation with symptom dimension or severity. OCD’s complex phenomenology may be characterized by changes in cerebellar WM connectivity across wide networks, as shown by DTI studies on OCD patients in both children and adults. Classification features in machine learning and clinical tools for diagnosing OCD and determining the prognosis of the disorder might both benefit from using cerebellar DTI data. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023.
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