Nodular Lymphoid Hyperplasia of Terminal Ileum: How to Avoid Overdiagnosis of Crohn’S Terminal Ileitis in Mr Enterography?

Nodular Lymphoid Hyperplasia of Terminal Ileum: How to Avoid Overdiagnosis of Crohn’S Terminal Ileitis in Mr Enterography? Publisher Pubmed

Montazeri SA^{1, 2} ; Mahfoodh FH² ; Naybandi Atashi S² ; Sima AR³ ; Saffar H⁴ ; Radmard AR²

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1. Department of Radiology, Mayo Clinic, FL, United States
2. Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences, North Kargar St, Tehran, 14117, Iran
3. Digestive Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Abdominal Radiology Published:2021

Abstract

Purpose: To investigate the magnetic resonance enterography (MRE) characteristics of nodular lymphoid hyperplasia (NLH) and Crohn’s terminal ileitis (CTI). Methods: Of 1552 MREs from November 2011 to July 2018, 61 individuals with biopsy-proven NLH (n = 24) and CTI (n = 37, 27 with active CTI) were selected based on the inclusion criteria. NLH cases were also followed up for median (range) of 40 (21–61) months. Two board-certified radiologists, blind to clinical data and diagnosis, reviewed MRE in consensus. Conventional, morphological, enhancement, and diffusion parameters were assessed. Mann–Whitney, χ2, and logistic regression analyses were conducted. Results: No NLH patient developed inflammatory bowel disease or lymphoproliferative disorders during the follow-up. Serosal surface irregularity (65% vs. 8%), pseudo-diverticula (27% vs. 0), and mesenteric fat involvement (38% vs. 4%) were more frequent in CTI than NLH (p < 0.01), while mucosal nodularity was more prevalent in NLH (71%) than CTI (19%) (p < 0.001). The upstream luminal diameter (15.0 vs. 12.5 mm, p = 0.015) and mural thickness (6.0 vs. 4.0 mm, p < 0.001) of the terminal ileum showed higher values in CTI than NLH. Conclusions: Unlike enhancement and diffusion parameters, morphological features (mucosal nodularity, serosal surface irregularity, and mesenteric fat involvement) could distinguish NLH from CTI regardless of CTI activity. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.

2. Potential Mr Enterography Features to Differentiate Primary Small Intestinal Lymphoma From Crohn Disease, American Journal of Roentgenology (2020)

3. A Practical Index to Distinguish Backwash Ileitis From Crohn's Terminal Ileitis in Mr Enterography, Inflammatory Bowel Diseases (2023)

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Amir Reza Radmard (3)

Reza Malekzadeh (2)

Style	Citing Format
MLA	Montazeri SA, et al.. "Nodular Lymphoid Hyperplasia of Terminal Ileum: How to Avoid Overdiagnosis of Crohn’S Terminal Ileitis in Mr Enterography?." Abdominal Radiology, vol. 46, no. 5, 2021, pp. 1846-1854.
APA	Montazeri SA, Mahfoodh FH, Naybandi Atashi S, Sima AR, Saffar H, Radmard AR (2021). Nodular Lymphoid Hyperplasia of Terminal Ileum: How to Avoid Overdiagnosis of Crohn’S Terminal Ileitis in Mr Enterography?. Abdominal Radiology, 46(5), 1846-1854.
Chicago	Montazeri SA, Mahfoodh FH, Naybandi Atashi S, Sima AR, Saffar H, Radmard AR. "Nodular Lymphoid Hyperplasia of Terminal Ileum: How to Avoid Overdiagnosis of Crohn’S Terminal Ileitis in Mr Enterography?." Abdominal Radiology 46, no. 5 (2021): 1846-1854.
Harvard	Montazeri SA et al. (2021) 'Nodular Lymphoid Hyperplasia of Terminal Ileum: How to Avoid Overdiagnosis of Crohn’S Terminal Ileitis in Mr Enterography?', Abdominal Radiology, 46(5), pp. 1846-1854.
Vancouver	Montazeri SA, Mahfoodh FH, Naybandi Atashi S, Sima AR, Saffar H, Radmard AR. Nodular Lymphoid Hyperplasia of Terminal Ileum: How to Avoid Overdiagnosis of Crohn’S Terminal Ileitis in Mr Enterography?. Abdominal Radiology. 2021;46(5):1846-1854.
BibTex	@article{ author = {Montazeri SA and Mahfoodh FH and Naybandi Atashi S and Sima AR and Saffar H and Radmard AR}, title = {Nodular Lymphoid Hyperplasia of Terminal Ileum: How to Avoid Overdiagnosis of Crohn’S Terminal Ileitis in Mr Enterography?}, journal = {Abdominal Radiology}, volume = {46}, number = {5}, pages = {1846-1854}, year = {2021} }
RIS	TY - JOUR AU - Montazeri SA AU - Mahfoodh FH AU - Naybandi Atashi S AU - Sima AR AU - Saffar H AU - Radmard AR TI - Nodular Lymphoid Hyperplasia of Terminal Ileum: How to Avoid Overdiagnosis of Crohn’S Terminal Ileitis in Mr Enterography? JO - Abdominal Radiology VL - 46 IS - 5 SP - 1846 EP - 1854 PY - 2021 ER -

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