Potassium Carbonate Catalyzed Intramolecular Post-Ugi Hydroamination Reaction Leading to N -Aryl Piperazine Derivatives

Potassium Carbonate Catalyzed Intramolecular Post-Ugi Hydroamination Reaction Leading to N -Aryl Piperazine Derivatives Publisher

Yazzaf R¹ ; Sayahi MH² ; Mahdavi M³

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1. School of Chemistry, College of Science, University of Tehran, PO Box 14155-6455, Tehran, Iran
2. Department of Chemistry, Payame Noor University, Tehran, Iran
3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Synlett Published:2025

Abstract

N -Arylpiperazines are prominent structures found in natural products and synthetic chemical entities, including therapeutic agents. In this work, we introduce a novel strategy for the effective synthesis of distinctive piperazine compounds through a post-Ugi cyclization under transition-metal-free conditions. This method involves the formation of a four-component Ugi adduct by combining an aldehyde, an isocyanide, a primary propargylamine, and an oxamic acid. Subsequently, an intramolecular alkyne hydroamination reaction occurs, leading to the formation of a piperazine derivative through carbon-nitrogen bond formation. The products have been characterized by 1 H and 13 C NMR spectroscopy. © 2025 Georg Thieme Verlag. All rights reserved.

Style	Citing Format
MLA	Yazzaf R, Sayahi MH, Mahdavi M. "Potassium Carbonate Catalyzed Intramolecular Post-Ugi Hydroamination Reaction Leading to N -Aryl Piperazine Derivatives." Synlett, vol. 36, no. 9, 2025, pp. 1219-1222.
APA	Yazzaf R, Sayahi MH, Mahdavi M (2025). Potassium Carbonate Catalyzed Intramolecular Post-Ugi Hydroamination Reaction Leading to N -Aryl Piperazine Derivatives. Synlett, 36(9), 1219-1222.
Chicago	Yazzaf R, Sayahi MH, Mahdavi M. "Potassium Carbonate Catalyzed Intramolecular Post-Ugi Hydroamination Reaction Leading to N -Aryl Piperazine Derivatives." Synlett 36, no. 9 (2025): 1219-1222.
Harvard	Yazzaf R, Sayahi MH, Mahdavi M (2025) 'Potassium Carbonate Catalyzed Intramolecular Post-Ugi Hydroamination Reaction Leading to N -Aryl Piperazine Derivatives', Synlett, 36(9), pp. 1219-1222.
Vancouver	Yazzaf R, Sayahi MH, Mahdavi M. Potassium Carbonate Catalyzed Intramolecular Post-Ugi Hydroamination Reaction Leading to N -Aryl Piperazine Derivatives. Synlett. 2025;36(9):1219-1222.
BibTex	@article{ author = {Yazzaf R and Sayahi MH and Mahdavi M}, title = {Potassium Carbonate Catalyzed Intramolecular Post-Ugi Hydroamination Reaction Leading to N -Aryl Piperazine Derivatives}, journal = {Synlett}, volume = {36}, number = {9}, pages = {1219-1222}, year = {2025} }
RIS	TY - JOUR AU - Yazzaf R AU - Sayahi MH AU - Mahdavi M TI - Potassium Carbonate Catalyzed Intramolecular Post-Ugi Hydroamination Reaction Leading to N -Aryl Piperazine Derivatives JO - Synlett VL - 36 IS - 9 SP - 1219 EP - 1222 PY - 2025 ER -

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