A Simple and Efficient Procedure Toward 2-Thioxoquinazolin-4(1H)-One Derivatives

A Simple and Efficient Procedure Toward 2-Thioxoquinazolin-4(1H)-One Derivatives Publisher

Ahmadi Shourkaei F¹ ; Rashidi Ranjbar P¹ ; Mahdavi M² ; Tuzun B³ ; Taslimi P⁴

Show Affiliations

1. School of Chemistry, College of Science, University of Tehran, Tehran, Iran
2. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
3. Plant and Animal Production Department, Technical Sciences Vocational School of Sivas, Sivas Cumhuriyet University, Sivas, Turkey
4. Department of Biotechnology, Faculty of Science, Bartin University, Bartin, Turkey

Source: Iranian Journal of Chemistry and Chemical Engineering Published:2024

Abstract

A facile synthetic route for constructing 2-thioxoquinazolin-4(1H)-one derivative through cyclization reactions using readily available starting materials 2-aminobenzoic acids, alkyl/aryl amines, and carbon disulfide is described. These reactions occur under mild conditions, producing the desired products with good to high yields. Molecular docking was conducted to assess the activities of the 2-thioxoquinazolin-4(1H)-one derivative against breast cancer protein (PDB ID: 1JNX), liver cancer protein (PDB ID: 2H80), and colon cancer protein (PDB ID: 4UYA). Furthermore, an ADME/T analysis was performed to evaluate the impact of these compounds on human metabolism. © 2024, Iranian Institute of Research and Development in Chemical Industries. All rights reserved.

Experts (# of related papers)

Tahmineh Akbarzadeh (1)

Mohammad Mahdavi (1)

Style	Citing Format
MLA	Ahmadi Shourkaei F, et al.. "A Simple and Efficient Procedure Toward 2-Thioxoquinazolin-4(1H)-One Derivatives." Iranian Journal of Chemistry and Chemical Engineering, vol. 43, no. 3, 2024, pp. 1103-1114.
APA	Ahmadi Shourkaei F, Rashidi Ranjbar P, Mahdavi M, Tuzun B, Taslimi P (2024). A Simple and Efficient Procedure Toward 2-Thioxoquinazolin-4(1H)-One Derivatives. Iranian Journal of Chemistry and Chemical Engineering, 43(3), 1103-1114.
Chicago	Ahmadi Shourkaei F, Rashidi Ranjbar P, Mahdavi M, Tuzun B, Taslimi P. "A Simple and Efficient Procedure Toward 2-Thioxoquinazolin-4(1H)-One Derivatives." Iranian Journal of Chemistry and Chemical Engineering 43, no. 3 (2024): 1103-1114.
Harvard	Ahmadi Shourkaei F et al. (2024) 'A Simple and Efficient Procedure Toward 2-Thioxoquinazolin-4(1H)-One Derivatives', Iranian Journal of Chemistry and Chemical Engineering, 43(3), pp. 1103-1114.
Vancouver	Ahmadi Shourkaei F, Rashidi Ranjbar P, Mahdavi M, Tuzun B, Taslimi P. A Simple and Efficient Procedure Toward 2-Thioxoquinazolin-4(1H)-One Derivatives. Iranian Journal of Chemistry and Chemical Engineering. 2024;43(3):1103-1114.
BibTex	@article{ author = {Ahmadi Shourkaei F and Rashidi Ranjbar P and Mahdavi M and Tuzun B and Taslimi P}, title = {A Simple and Efficient Procedure Toward 2-Thioxoquinazolin-4(1H)-One Derivatives}, journal = {Iranian Journal of Chemistry and Chemical Engineering}, volume = {43}, number = {3}, pages = {1103-1114}, year = {2024} }
RIS	TY - JOUR AU - Ahmadi Shourkaei F AU - Rashidi Ranjbar P AU - Mahdavi M AU - Tuzun B AU - Taslimi P TI - A Simple and Efficient Procedure Toward 2-Thioxoquinazolin-4(1H)-One Derivatives JO - Iranian Journal of Chemistry and Chemical Engineering VL - 43 IS - 3 SP - 1103 EP - 1114 PY - 2024 ER -

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