The Diverse Roles of Long Non-Coding Rna Hottip in Breast and Gynecological Cancer Progression

The Diverse Roles of Long Non-Coding Rna Hottip in Breast and Gynecological Cancer Progression Publisher Pubmed

Dari MAG¹ ; Radmehr S⁴ ; Khodadadi A⁵ ; Shooshtari MK⁶ ; Kempisty B^{7, 8, 9, 10} ; Farzaneh M^{2, 5, 11} ; Mohadeseh SS³

Show Affiliations

1. Department of Obstetrics and Gynecology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2. Clinical Research Development Unit, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3. Department of Laboratory, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
4. Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5. Cancer, Environmental and Petroleum Pollutants Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
6. Chronic Renal Failure Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
7. Department of Human Morphology and Embryology, Division of Anatomy, Wroclaw Medical University, Poland
8. Department of Veterinary Surgery, Institute of Veterinary Medicine Nicolaus Copernicus University, Torun, Poland
9. Physiology Graduate Faculty, North Carolina State University, Raleigh, 27695, NC, United States
10. Center of Assisted Reproduction, Department of Obstetrics and Gynecology, University Hospital and Masaryk University, Brno, Czech Republic
11. Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Source: Current Molecular Medicine Published:2025

Abstract

Long non-coding RNAs (lncRNAs) play vital roles in the development and progression of various tumors through multiple mechanisms. Among these, HOTTIP (HOXA transcript at the distal tip) stands out as an intriguing candidate with diverse functions in several malignancies, including breast cancer and gynecologic cancers such as ovarian, cervical, and endometrial cancers, which are significant global health concerns. HOTTIP interacts with key signaling pathways associated with these cancers, including Wnt/β-catenin, PI3K/AKT, and MEK/ERK pathways, enhancing their activation and downstream effects. Its influence extends to crucial aspects of cancer biology, such as cell proliferation, apoptosis, migration, invasion, angiogenesis, and epithelial-mesenchymal transition (EMT). Additionally, HOTTIP plays a pivotal role in the pathogenesis of breast and gynecologic tumors by sponging various microRNAs (miRNAs) and regulating the expression of mRNAs involved in critical molecular processes. This dysregulation is often associated with poor clinical outcomes, advanced disease stages, and distant metastases. Understanding the functional roles of HOTTIP in these cancers is essential for developing targeted therapeutic strategies. This review aims to explore the emerging roles of HOTTIP in breast and gynecologic cancers. © 2025 Bentham Science Publishers.

Style	Citing Format
MLA	Dari MAG, et al.. "The Diverse Roles of Long Non-Coding Rna Hottip in Breast and Gynecological Cancer Progression." Current Molecular Medicine, vol. , no. , 2025, pp. -.
APA	Dari MAG, Radmehr S, Khodadadi A, Shooshtari MK, Kempisty B, Farzaneh M, Mohadeseh SS (2025). The Diverse Roles of Long Non-Coding Rna Hottip in Breast and Gynecological Cancer Progression. Current Molecular Medicine, (), -.
Chicago	Dari MAG, Radmehr S, Khodadadi A, Shooshtari MK, Kempisty B, Farzaneh M, Mohadeseh SS. "The Diverse Roles of Long Non-Coding Rna Hottip in Breast and Gynecological Cancer Progression." Current Molecular Medicine , no. (2025): -.
Harvard	Dari MAG et al. (2025) 'The Diverse Roles of Long Non-Coding Rna Hottip in Breast and Gynecological Cancer Progression', Current Molecular Medicine, (), pp. -.
Vancouver	Dari MAG, Radmehr S, Khodadadi A, Shooshtari MK, Kempisty B, Farzaneh M, et al.. The Diverse Roles of Long Non-Coding Rna Hottip in Breast and Gynecological Cancer Progression. Current Molecular Medicine. 2025;():-.
BibTex	@article{ author = {Dari MAG and Radmehr S and Khodadadi A and Shooshtari MK and Kempisty B and Farzaneh M and Mohadeseh SS}, title = {The Diverse Roles of Long Non-Coding Rna Hottip in Breast and Gynecological Cancer Progression}, journal = {Current Molecular Medicine}, volume = {}, number = {}, pages = {-}, year = {2025} }
RIS	TY - JOUR AU - Dari MAG AU - Radmehr S AU - Khodadadi A AU - Shooshtari MK AU - Kempisty B AU - Farzaneh M AU - Mohadeseh SS TI - The Diverse Roles of Long Non-Coding Rna Hottip in Breast and Gynecological Cancer Progression JO - Current Molecular Medicine VL - IS - SP - EP - PY - 2025 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract