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Micrornas, Long Non-Coding Rnas, and Circular Rnas and Gynecological Cancers: Focus on Metastasis Publisher



Rezaee A1 ; Ahmadpour S2 ; Jafari A3 ; Aghili S4 ; Zadeh SST5 ; Rajabi A6, 7 ; Raisi A6, 7 ; Hamblin MR8 ; Mahjoubintehran M9, 10 ; Derakhshan M11
Authors
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Authors Affiliations
  1. 1. Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Biotechnology Department, Faculty of Chemistry, University of Kashan, Kashan, Iran
  3. 3. Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Gynecology and Obstetrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  7. 7. Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran
  8. 8. Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, South Africa
  9. 9. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  10. 10. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  11. 11. Shahid Beheshti Fertility Clinic, Department of Gynecology and Obsteterics, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Frontiers in Oncology Published:2023


Abstract

Gynecologic cancer is a significant cause of death in women worldwide, with cervical cancer, ovarian cancer, and endometrial cancer being among the most well-known types. The initiation and progression of gynecologic cancers involve a variety of biological functions, including angiogenesis and metastasis—given that death mostly occurs from metastatic tumors that have invaded the surrounding tissues. Therefore, understanding the molecular pathways underlying gynecologic cancer metastasis is critical for enhancing patient survival and outcomes. Recent research has revealed the contribution of numerous non-coding RNAs (ncRNAs) to metastasis and invasion of gynecologic cancer by affecting specific cellular pathways. This review focuses on three types of gynecologic cancer (ovarian, endometrial, and cervical) and three kinds of ncRNAs (long non-coding RNAs, microRNAs, and circular RNAs). We summarize the detailed role of non-coding RNAs in the different pathways and molecular interactions involved in the invasion and metastasis of these cancers. Copyright © 2023 Rezaee, Ahmadpour, Jafari, Aghili, Zadeh, Rajabi, Raisi, Hamblin, Mahjoubin-Tehran and Derakhshan.
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