Fecal Microbiota Transplantation for Recurrent Clostridium Difficile Infection in Patients With Inflammatory Bowel Disease; Case Series



Daryani NE¹ ; Deihim T² ; Paydari H³ ; Niksirat A² ; Alebouyeh M⁴ ; Mostafaei FSG⁴ Show Affiliations
Source: Govaresh Published:2017

Abstract

Clostridium difficile infection in patients with inflammatory bowel disease (IBD) is associated with more severe disease, longer hospital admission, higher treatment costs, higher risk of colectomy and mortality rate. The classic endoscopic view of the disease is adherent whitish-yellowish multifocal membrane, defined as psudo-membrane. Using stool polymerase chain reaction (PCR) is the best way for identifying this organism. Patients with mild to moderate infection are treated with oral metronidazole, while severe infections are treated with oral vancomycin for 10 days. The first recurrence of clostridium difficile infection is treated with the same regimen as the initial episode, however the second recurrence is treated with vancomycin pulse therapy. In the third recurrence, fecal microbiota transplantation (FMT) is one of the treatment choices. This study is a report of three successful FMT in our patients.