Toxigenic Clostridium Difficile-Mediated Diarrhoea in Hematopoietic Stem Cell Transplantation In-Patients: Rapid Diagnosis and Efficient Treatment

Toxigenic Clostridium Difficile-Mediated Diarrhoea in Hematopoietic Stem Cell Transplantation In-Patients: Rapid Diagnosis and Efficient Treatment Publisher Pubmed

Khodaparast S¹ ; Mohabati Mobarez A¹ ; Khoramabadi N¹ ; Vasei M² ; Saberifiroozi M³

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1. Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
2. Cell-based Therapies Research Centre, Digestive Disease Research Institute, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3. Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Epidemiology and Infection Published:2021

Abstract

Allogenic hematopoietic stem cell transplant (HSCT) recipients are susceptible to any kind of infectious agents including Clostridium difficile. We studied 86 allogenic-HSCT patients who faced diarrhoea while receiving antibiotics. DNA from stool samples were explored for the presence of C. difficile toxin genes (tcdA; tcdB) by multiplex real-time PCR. Results showed nine toxigenic C. difficile amongst which seven were positive for both toxins and two were positive for tcdB. Six of toxigenic C. difficile organisms harbouring both toxin genes were also isolated by toxigenic culture. Clostridium difficile infection was controlled successfully with oral Metronidazole and Vancomycin in the confirmed infected patients. Copyright © The Author(s), 2021. Published by Cambridge University Press.

2. Antibiotic-Associated Diarrhea Mediated by Toxigenic Clostridioides Difficile Infection in Iran: A Clinical Survey by Multiplex Real-Time Polymerase Chain Reaction and Toxigenic Culture, Govaresh (2022)

Experts (# of related papers)

Mehdi Saberi Firoozi (1)

Mohammad Vasei (1)

Style	Citing Format
MLA	Khodaparast S, et al.. "Toxigenic Clostridium Difficile-Mediated Diarrhoea in Hematopoietic Stem Cell Transplantation In-Patients: Rapid Diagnosis and Efficient Treatment." Epidemiology and Infection, vol. 149, no. , 2021, pp. -.
APA	Khodaparast S, Mohabati Mobarez A, Khoramabadi N, Vasei M, Saberifiroozi M (2021). Toxigenic Clostridium Difficile-Mediated Diarrhoea in Hematopoietic Stem Cell Transplantation In-Patients: Rapid Diagnosis and Efficient Treatment. Epidemiology and Infection, 149(), -.
Chicago	Khodaparast S, Mohabati Mobarez A, Khoramabadi N, Vasei M, Saberifiroozi M. "Toxigenic Clostridium Difficile-Mediated Diarrhoea in Hematopoietic Stem Cell Transplantation In-Patients: Rapid Diagnosis and Efficient Treatment." Epidemiology and Infection 149, no. (2021): -.
Harvard	Khodaparast S et al. (2021) 'Toxigenic Clostridium Difficile-Mediated Diarrhoea in Hematopoietic Stem Cell Transplantation In-Patients: Rapid Diagnosis and Efficient Treatment', Epidemiology and Infection, 149(), pp. -.
Vancouver	Khodaparast S, Mohabati Mobarez A, Khoramabadi N, Vasei M, Saberifiroozi M. Toxigenic Clostridium Difficile-Mediated Diarrhoea in Hematopoietic Stem Cell Transplantation In-Patients: Rapid Diagnosis and Efficient Treatment. Epidemiology and Infection. 2021;149():-.
BibTex	@article{ author = {Khodaparast S and Mohabati Mobarez A and Khoramabadi N and Vasei M and Saberifiroozi M}, title = {Toxigenic Clostridium Difficile-Mediated Diarrhoea in Hematopoietic Stem Cell Transplantation In-Patients: Rapid Diagnosis and Efficient Treatment}, journal = {Epidemiology and Infection}, volume = {149}, number = {}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Khodaparast S AU - Mohabati Mobarez A AU - Khoramabadi N AU - Vasei M AU - Saberifiroozi M TI - Toxigenic Clostridium Difficile-Mediated Diarrhoea in Hematopoietic Stem Cell Transplantation In-Patients: Rapid Diagnosis and Efficient Treatment JO - Epidemiology and Infection VL - 149 IS - SP - EP - PY - 2021 ER -

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