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Toxigenic Clostridium Difficile-Mediated Diarrhoea in Hematopoietic Stem Cell Transplantation In-Patients: Rapid Diagnosis and Efficient Treatment Publisher Pubmed



Khodaparast S1 ; Mohabati Mobarez A1 ; Khoramabadi N1 ; Vasei M2 ; Saberifiroozi M3
Authors
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Authors Affiliations
  1. 1. Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  2. 2. Cell-based Therapies Research Centre, Digestive Disease Research Institute, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Epidemiology and Infection Published:2021


Abstract

Allogenic hematopoietic stem cell transplant (HSCT) recipients are susceptible to any kind of infectious agents including Clostridium difficile. We studied 86 allogenic-HSCT patients who faced diarrhoea while receiving antibiotics. DNA from stool samples were explored for the presence of C. difficile toxin genes (tcdA; tcdB) by multiplex real-time PCR. Results showed nine toxigenic C. difficile amongst which seven were positive for both toxins and two were positive for tcdB. Six of toxigenic C. difficile organisms harbouring both toxin genes were also isolated by toxigenic culture. Clostridium difficile infection was controlled successfully with oral Metronidazole and Vancomycin in the confirmed infected patients. Copyright © The Author(s), 2021. Published by Cambridge University Press.