Diversity of Mosaic Pbp2x Families in Penicillin-Resistant Streptococcus Pneumoniae From Iran and Romania

Diversity of Mosaic Pbp2x Families in Penicillin-Resistant Streptococcus Pneumoniae From Iran and Romania Publisher Pubmed

Mousavi SF¹ ; Pana M² ; Feizabadi M³ ; Jalali P¹ ; Ghita M³ ; Denapaite D⁴ ; Hakenbeck R⁴

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1. Department of Microbiology, Pasteur Institute of Iran, Tehran, Iran
2. Cantacuzino National Institute of Research-Development for Microbiology and Immunology, Bucharest, Romania
3. Department of Microbiology, Faculty of Medicine, Tehran University of Medical Science, Tehran, Iran
4. Department of Microbiology, University of Kaiserslautern, Kaiserslautern, Germany

Source: Antimicrobial Agents and Chemotherapy Published:2017

Abstract

Penicillin-resistant Streptococcus pneumoniae strains are found at high rates in Romania and Iran. The mosaic structure of PBP2x was investigated in 9 strains from Iran and in 15 strains from Romania to understand their evolutionary history. Mutations potentially important for -lactam resistance were identified by comparison of the PBP2x sequences with the sequence of the related PBP2x of reference penicillin-sensitive S. mitis strains. Two main PBP2x mosaic gene families were recognized. Eight Iranian strains expressed PBP2x variants in group 1, which had a mosaic block highly related to PBP2x of the Spain23F-1 clone, which is widespread among international penicillin-resistant S. pneumoniae clones. A second unique PBP2x group was observed in Romanian strains; furthermore, three PBP2x single mosaic variants were found. Sequence blocks of penicillin-sensitive strain S. mitis 658 were common among PBP2x variants from strains from both countries. Each PBP2x group contained specific signature mutations within the transpeptidase domain, documenting the existence of distinct mutational pathways for the development of penicillin resistance. © 2017 Mousavi et al.

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Style	Citing Format
MLA	Mousavi SF, et al.. "Diversity of Mosaic Pbp2x Families in Penicillin-Resistant Streptococcus Pneumoniae From Iran and Romania." Antimicrobial Agents and Chemotherapy, vol. 61, no. 12, 2017, pp. -.
APA	Mousavi SF, Pana M, Feizabadi M, Jalali P, Ghita M, Denapaite D, Hakenbeck R (2017). Diversity of Mosaic Pbp2x Families in Penicillin-Resistant Streptococcus Pneumoniae From Iran and Romania. Antimicrobial Agents and Chemotherapy, 61(12), -.
Chicago	Mousavi SF, Pana M, Feizabadi M, Jalali P, Ghita M, Denapaite D, Hakenbeck R. "Diversity of Mosaic Pbp2x Families in Penicillin-Resistant Streptococcus Pneumoniae From Iran and Romania." Antimicrobial Agents and Chemotherapy 61, no. 12 (2017): -.
Harvard	Mousavi SF et al. (2017) 'Diversity of Mosaic Pbp2x Families in Penicillin-Resistant Streptococcus Pneumoniae From Iran and Romania', Antimicrobial Agents and Chemotherapy, 61(12), pp. -.
Vancouver	Mousavi SF, Pana M, Feizabadi M, Jalali P, Ghita M, Denapaite D, et al.. Diversity of Mosaic Pbp2x Families in Penicillin-Resistant Streptococcus Pneumoniae From Iran and Romania. Antimicrobial Agents and Chemotherapy. 2017;61(12):-.
BibTex	@article{ author = {Mousavi SF and Pana M and Feizabadi M and Jalali P and Ghita M and Denapaite D and Hakenbeck R}, title = {Diversity of Mosaic Pbp2x Families in Penicillin-Resistant Streptococcus Pneumoniae From Iran and Romania}, journal = {Antimicrobial Agents and Chemotherapy}, volume = {61}, number = {12}, pages = {-}, year = {2017} }
RIS	TY - JOUR AU - Mousavi SF AU - Pana M AU - Feizabadi M AU - Jalali P AU - Ghita M AU - Denapaite D AU - Hakenbeck R TI - Diversity of Mosaic Pbp2x Families in Penicillin-Resistant Streptococcus Pneumoniae From Iran and Romania JO - Antimicrobial Agents and Chemotherapy VL - 61 IS - 12 SP - EP - PY - 2017 ER -

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