High-Level Aminoglycoside Resistance in Enterococcus Faecalis and Enterococcus Faecium; As a Serious Threat in Hospitals

High-Level Aminoglycoside Resistance in Enterococcus Faecalis and Enterococcus Faecium; As a Serious Threat in Hospitals Publisher Pubmed

Khodabandeh M¹ ; Mohammadi M² ; Abdolsalehi MR¹ ; Hasannejadbibalan M³ ; Gholami M⁴ ; Alvandimanesh A⁵ ; Pournajaf A⁶ ; Rajabnia R⁷

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1. Department of Infectious Diseases, Pediatricâ€™s Center of Excellence, Childrenâ€™s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
2. Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
3. Department of Microbiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
4. Department of Microbiology and Virology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
5. Department of pathology, Shafa hospital, Qazvin University of Medical Sci-ences, Qazvin, Iran
6. Department of Microbiology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
7. Infectious Diseases and Tropical Medicine Research Center, Babol University of Medical Sciences, Babol, Iran

Source: Infectious Disorders - Drug Targets Published:2020

Abstract

Aims and Objectives: The present work aimed to evaluate the frequency of aminogly-coside-modifying enzymes encoding genes in the E. faecalis and E. faecium and their antibiotic resistance profile. Methods: A total of 305 different clinical samples were subjected for identification and antibiotic susceptibility test. The high-level aminoglycoside resistance was identified by MIC and Kirby Bauer disc diffusion method. The prevalence of aac (6')-Ie-aph (2'')-Ia, aph (3')-IIIa and ant (4')-Ia genes was determined by multiplex-PCR. In total, 100 enterococci strains were isolated. The prevalence of E. faecalis and E. faecium isolates was 78% and 22%, respectively. Results: All isolates were susceptible to linezolid. So, all E. faecalis were susceptible to vanco-mycin but, 36.4% of E. faecium were resistant to it. The prevalence of multiple drug resistance strains was 100% and 67.9% of E. faecium and E. faecalis, respectively. High-level-gentamicin and streptomycin resistant rates were as follows; 26.9% and 73.1% of E. faecalis and 77.3% and 90.1% of E. faecium. Conclucion: The results of the current study showed a high frequency of aac (6')-Ie-aph (2'')-Ia genes among enterococcal isolates. A high rate of resistance to antimicrobials in Enterococcus is obviously problematic, and a novel policy is needed to decrease resistance in these microorganisms. © 2020 Bentham Science Publishers.

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Style	Citing Format
MLA	Khodabandeh M, et al.. "High-Level Aminoglycoside Resistance in Enterococcus Faecalis and Enterococcus Faecium; As a Serious Threat in Hospitals." Infectious Disorders - Drug Targets, vol. 20, no. 2, 2020, pp. 223-228.
APA	Khodabandeh M, Mohammadi M, Abdolsalehi MR, Hasannejadbibalan M, Gholami M, Alvandimanesh A, Pournajaf A, Rajabnia R (2020). High-Level Aminoglycoside Resistance in Enterococcus Faecalis and Enterococcus Faecium; As a Serious Threat in Hospitals. Infectious Disorders - Drug Targets, 20(2), 223-228.
Chicago	Khodabandeh M, Mohammadi M, Abdolsalehi MR, Hasannejadbibalan M, Gholami M, Alvandimanesh A, Pournajaf A, Rajabnia R. "High-Level Aminoglycoside Resistance in Enterococcus Faecalis and Enterococcus Faecium; As a Serious Threat in Hospitals." Infectious Disorders - Drug Targets 20, no. 2 (2020): 223-228.
Harvard	Khodabandeh M et al. (2020) 'High-Level Aminoglycoside Resistance in Enterococcus Faecalis and Enterococcus Faecium; As a Serious Threat in Hospitals', Infectious Disorders - Drug Targets, 20(2), pp. 223-228.
Vancouver	Khodabandeh M, Mohammadi M, Abdolsalehi MR, Hasannejadbibalan M, Gholami M, Alvandimanesh A, et al.. High-Level Aminoglycoside Resistance in Enterococcus Faecalis and Enterococcus Faecium; As a Serious Threat in Hospitals. Infectious Disorders - Drug Targets. 2020;20(2):223-228.
BibTex	@article{ author = {Khodabandeh M and Mohammadi M and Abdolsalehi MR and Hasannejadbibalan M and Gholami M and Alvandimanesh A and Pournajaf A and Rajabnia R}, title = {High-Level Aminoglycoside Resistance in Enterococcus Faecalis and Enterococcus Faecium; As a Serious Threat in Hospitals}, journal = {Infectious Disorders - Drug Targets}, volume = {20}, number = {2}, pages = {223-228}, year = {2020} }
RIS	TY - JOUR AU - Khodabandeh M AU - Mohammadi M AU - Abdolsalehi MR AU - Hasannejadbibalan M AU - Gholami M AU - Alvandimanesh A AU - Pournajaf A AU - Rajabnia R TI - High-Level Aminoglycoside Resistance in Enterococcus Faecalis and Enterococcus Faecium; As a Serious Threat in Hospitals JO - Infectious Disorders - Drug Targets VL - 20 IS - 2 SP - 223 EP - 228 PY - 2020 ER -

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