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Hla Study in Iranian Desert Yazd Province Inhabitants Publisher Pubmed



Suareztrujillo F1, 2 ; Amirzargar A3 ; Hadinedoushan H4 ; Juarez I1, 2 ; Nikbin B3 ; Gilmartin R1 ; Vaqueroyuste C1, 2 ; Arnaizvillena A1, 2
Authors
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Authors Affiliations
  1. 1. Department of Immunology, University Complutense of Madrid, Spain
  2. 2. Instituto de Investigacion Sanitaria Gregorio Maranon, Madrid, Spain
  3. 3. Molecular Immunology Research Center, Medical School, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Immunology, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran

Source: Human Immunology Published:2023


Abstract

Yazd City (1,200,000 inhabitants) is placed in the middle of its Iran desert province and it was constructed on a oasis in ancient times.However,it was a central point on the Silk Road and merchants from both Asia and Mediterranean/European areas crossed through Yazd City.We have studied HLA-A,-B,-DRB1 and DQB1 alleles in Yazd population.Analysys of nine most frequent extended class I and class II haplotypes shows that four of them are specific of this population.The other six haplotypes are also found in Asian and Mediterranean populations in significant frequency. This supports that the nowadays relatively isolated in desert Yazd area also contains people that may bear HLA genes probably originated because of long lasting merchants route between Europe and Asia through the European/Asian Silk Road in addition to other HLA genes close to other Iranian populations, including Kurds. © 2023 The Author(s)