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Burden of Disease Attributable to Vitamin a Deficiency in Iranian Population Aged Less Than Five Years: Findings From the Global Burden of Disease Study 2010 Publisher



Bahreynian M1 ; Qorbani M2, 3 ; Naderimagham S3, 4 ; Nejatinamini S3 ; Ataiejafari A5 ; Sharifi F6 ; Saqib F1 ; Khajavi A3 ; Mansourian M7 ; Ahmadishokouh AA8 ; Asayesh H9 ; Safari O2 ; Kelishadi R1
Authors
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Authors Affiliations
  1. 1. Isfahan University of Medical Sciences, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Hezarjerib Ave, Isfahan, Iran
  2. 2. Alborz University of Medical Sciences, Non-Communicable Diseases Research Center, Baghestan Boulevard, Karaj, 31485/56, Iran
  3. 3. Tehran University of Medical Sciences, Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran, Iran
  4. 4. Tehran University of Medical Sciences, Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran, Iran
  5. 5. Islamic Azad University, Department of Nutrition, Science and Research Branch, Tehran, Iran
  6. 6. Tehran University of Medical Sciences, Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran, Iran
  7. 7. Iran University of Medical Sciences, Health Management and Economics Research Center, Department of Health Education and Promotion, Tehran, Iran
  8. 8. Tarbiat Modares University, Department of Applied Linguistics, Tehran, Iran
  9. 9. Qom University of Medical Sciences, Department of Medical Emergencies, Qom, Iran

Source: Journal of Diabetes and Metabolic Disorders Published:2017


Abstract

Background: Vitamin A deficiency (VAD) is considered as one of the most serious public health concerns in developing countriesand the leading cause of mortality in under-five-year-old children.A large number of young children and pregnant women especially in low-income, non-industrialized communities are more susceptible to VAD. This study aims to report the burden of disease (BOD) attributable to VAD in Iranian population aged less than 5years by using data of the Global Burden of Disease (GBD) study 2010. Methods: The GBD 2010 study calculated the proportion of deaths, years of life lost (YLLs), and years lived with disability (YLDs) and disability-adjusted life years (DALYs) attributable to VAD by using the comparative risk assessment (CRA). VAD defined as low serum retinol concentrations (plasma retinol concentration<0.70 umole/L) among children aged less than five. The VAD outcomes consisted of mortality due to diarrhea, measles, malaria, neglected infectious diseases, morbidity due to malaria (children<5years), low birth weight and other perinatal conditions. Uncertainty in the estimates is presented as 95% uncertainty interval (UI). Results: In 1990, there were 371 (95% UI: 166,665) DALYs due to VAD per 100,000 under five-year-old Iranian children in both sexes. The DALYs rate had a downward trend throughout the following years and reached to 76 (95% UI: 33-139)in 2010.The DALYs in children aged under 5years was 378 (95% UI: 153-747) years for boys and 363 (95% UI: 148-692) years for girls in 1990 which fell to 79 (95% UI: 32-149) and 73 (95% UI: 29-138) in boys and girls in 2010, respectively. The rates of YLDs attributable to VAD changed in both sexes from 87(95% UI: 34-162) in 1990 to 46 (95% UI: 17-69) in 2010. The highest rate of YLDs attributed to VAD was observed in children aged 1-4. On the other hand, the YLLs were mostly in the 0-1-year-oldchildren in all years except 2010. Conclusion: It was found that DALYs attributable to VAD in 1990, followed by a considerable reduction rate after a period of two decades, in 2010. Additional studies on the burden of diseases particularly at sub-national level with more accurate data are recommended. © 2017 The Author(s).
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