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Findings From the Meta-Analysis on Whole-Grain Consumption and Biomarkers of Systemic Inflammation Are Misleading Publisher Pubmed



Sadeghian M1, 2 ; Sadeghi O3, 4 ; Esmaillzadeh A2, 4, 5
Authors
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Authors Affiliations
  1. 1. Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of the American College of Nutrition Published:2019


Abstract

We have with great interest read the recent article by Hajihashemi et al. which systematically reviewed and meta-analyzed a number of published clinical trials about the effect of whole grains on serum levels of hs-CRP (high sensitiviy C-reactive protein), IL-6 (interlukin-6), TNF-α (tumor necrosis factor-α). The findings suggested that consumption of whole grains significantly decreased serum levels of hs-CRP and IL-6, but not TNF-α, compared with the control group. It is an interesting study, but there are some methodological limitations and missing data that need to be addressed. Therefore, we believe that the conclusions were misleading and further comprehensive meta-analysis is required to explain the effect of whole grain intake on serum concentrations of inflammatory biomarkers. © 2019, © 2019 American College of Nutrition.
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Ahmad Esmaillzadeh (4)
Bagher Larijani (2)