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Biochemical and Histopathological Evidence on Beneficial Effects of Standardized Extract From Tragopogon Graminifolius As a Dietary Supplement in Fatty Liver: Role of Oxidative Stress Publisher Pubmed



Sadeghi A1 ; Bahramsoltani R2 ; Rahimi R2 ; Farzaei MH3, 4 ; Farzaei F4 ; Haghighi ZMS5 ; Abdollahi M6
Authors
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Authors Affiliations
  1. 1. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
  2. 2. Department of Traditional Pharmacy, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  4. 4. Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  5. 5. Department of Pathology, Faculty of Veterinary Medicine, Razi University of Kermanshah, Kermanshah, Iran
  6. 6. Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Dietary Supplements Published:2018


Abstract

Nonalcoholic fatty liver disease (FLD) is a worldwide common liver disorder. Tragopogon graminifolius is used as a dietary supplement for liver disorders. This study aimed to assess the beneficial effects of a standardized preparation from T. graminifolius extract (TGE) in animal model of FLD induced by high-fat diet (HFD). The standardization of TGE based on phenolic compounds was performed using high-performance liquid chromatography (HPLC) analysis. The HFD induced metabolic and hepatic damages. TGE significantly reduced the elevations of serum triglyceride, cholesterol, low-density lipoprotein (LDL), and hepatic enzymes (p =.001 for 25, 50, and 100 mg/kg of TGE). Histopathological studies also confirmed beneficial effects of TGE in FLD. Activity of total antioxidant power, content of total thiol, myeloperoxidase (MPO) enzyme activity, and lipid peroxidation were significantly improved (p <.001). Dietary supplementation with TGE results in improvement of biochemical as well as histopathological parameters. Clinical trials are warranted to prove its efficacy and tolerability in patients with FLD. © 2018 Taylor & Francis Group, LLC.
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