Efficacy of Topical Application of Standardized Extract of Tragopogon Graminifolius in the Healing Process of Experimental Burn Wounds

Efficacy of Topical Application of Standardized Extract of Tragopogon Graminifolius in the Healing Process of Experimental Burn Wounds Publisher

Heidari M^{1, 2} ; Bahramsoltani R³ ; Abdolghaffari AH^{4, 5} ; Rahimi R³ ; Esfandyari M¹ ; Baeeri M⁵ ; Hassanzadeh G⁶ ; Abdollahi M⁵ ; Farzaei MH^{7, 8}

Show Affiliations

1. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Pharmaceutics, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
3. Department of Pharmacy in Persian Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
5. Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
6. Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
7. Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
8. Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Source: Journal of Traditional and Complementary Medicine Published:2019

Abstract

Tragopogon graminifolius DC. is a perennial plant from the family Asteraceae which grows in West parts of Iran. Several biological activities like antimicrobial, antioxidant and anti-inflammatory effects are reported for the plant. The aim of this study was to assess the wound healing activity of standardized extract from T. graminifolius (TG) aerial parts. Topical standardized TG extract with 5% and 10% concentrations in eucerine base was assessed for its healing properties on second degree burn in rats during a 14-day period. Biomarkers of oxidative damage including total antioxidant power, lipid peroxidation and total thiol molecules of the skin tissue samples were also evaluated. Results showed that 10%TG had the best efficacy with 80 ± 3% wound closure and tissue repair in comparison to negative control (p < 0.05). Significant reduction of tissue oxidative stress biomarkers was also observed. Histological analyses confirmed wound healing activity of TG extract, as well. Considering the antioxidative stress and anti-inflammatory activities of TG, explained by the high content of phenolic compounds of the plant, standardized TG extract could be considered as a natural remedy for the treatment of burn wounds. Further clinical studies are suggested to confirm the effectiveness of TG as a wound healing agent. © 2018 Center for Food and Biomolecules, National Taiwan University

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Mohammad Abdollahi (14)

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Style	Citing Format
MLA	Heidari M, et al.. "Efficacy of Topical Application of Standardized Extract of Tragopogon Graminifolius in the Healing Process of Experimental Burn Wounds." Journal of Traditional and Complementary Medicine, vol. 9, no. 1, 2019, pp. 54-59.
APA	Heidari M, Bahramsoltani R, Abdolghaffari AH, Rahimi R, Esfandyari M, Baeeri M, Hassanzadeh G, Abdollahi M, Farzaei MH (2019). Efficacy of Topical Application of Standardized Extract of Tragopogon Graminifolius in the Healing Process of Experimental Burn Wounds. Journal of Traditional and Complementary Medicine, 9(1), 54-59.
Chicago	Heidari M, Bahramsoltani R, Abdolghaffari AH, Rahimi R, Esfandyari M, Baeeri M, Hassanzadeh G, Abdollahi M, Farzaei MH. "Efficacy of Topical Application of Standardized Extract of Tragopogon Graminifolius in the Healing Process of Experimental Burn Wounds." Journal of Traditional and Complementary Medicine 9, no. 1 (2019): 54-59.
Harvard	Heidari M et al. (2019) 'Efficacy of Topical Application of Standardized Extract of Tragopogon Graminifolius in the Healing Process of Experimental Burn Wounds', Journal of Traditional and Complementary Medicine, 9(1), pp. 54-59.
Vancouver	Heidari M, Bahramsoltani R, Abdolghaffari AH, Rahimi R, Esfandyari M, Baeeri M, et al.. Efficacy of Topical Application of Standardized Extract of Tragopogon Graminifolius in the Healing Process of Experimental Burn Wounds. Journal of Traditional and Complementary Medicine. 2019;9(1):54-59.
BibTex	@article{ author = {Heidari M and Bahramsoltani R and Abdolghaffari AH and Rahimi R and Esfandyari M and Baeeri M and Hassanzadeh G and Abdollahi M and Farzaei MH}, title = {Efficacy of Topical Application of Standardized Extract of Tragopogon Graminifolius in the Healing Process of Experimental Burn Wounds}, journal = {Journal of Traditional and Complementary Medicine}, volume = {9}, number = {1}, pages = {54-59}, year = {2019} }
RIS	TY - JOUR AU - Heidari M AU - Bahramsoltani R AU - Abdolghaffari AH AU - Rahimi R AU - Esfandyari M AU - Baeeri M AU - Hassanzadeh G AU - Abdollahi M AU - Farzaei MH TI - Efficacy of Topical Application of Standardized Extract of Tragopogon Graminifolius in the Healing Process of Experimental Burn Wounds JO - Journal of Traditional and Complementary Medicine VL - 9 IS - 1 SP - 54 EP - 59 PY - 2019 ER -

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