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L-Carnosine As an Adjuvant to Fluvoxamine in Treatment of Obsessive Compulsive Disorder: A Randomized Double-Blind Study Publisher Pubmed



Arabzadeh S1 ; Shahhossenie M1 ; Mesgarpour B2 ; Rezaei F3 ; Shalbafan MR4 ; Ghiasi Z5 ; Akhondzadeh S1
Authors
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Authors Affiliations
  1. 1. Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. National Institute for Medical Research Development (NIMAD), Tehran, Iran
  3. 3. Qods Hospital, Kurdistan University of Medical Sciences, Sanandaj, Iran
  4. 4. Mental Health Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Psychiatry, Zahedan University of Medical Sciences, Zahedan, Iran

Source: Human Psychopharmacology Published:2017


Abstract

Background: Dysregulation of glutamate is implicated in the pathogenesis of obsessive-compulsive disorder (OCD). Consistently, glutamate-modulating agents, such as riluzole and memantine have been used in OCD treatment. Previous research has identified some neuroprotective role for L-carnosine potentially via its modulatory effect on glutamate. Here, we assessed the efficacy of L-carnosine as adjuvant to fluvoxamine in OCD treatment. Methods: Forty-four patients diagnosed with moderate to severe OCD were recruited in a randomized double-blind trial. Patients received either L-carnosine or placebo as adjuvant to fluvoxamine for 10 weeks. The Yale- Brown Obsessive Compulsive Scale (Y-BOCS) was used for assessing the severity of symptoms at baseline and at weeks 4, 8, and 10. Results: General linear model repeated measure showed significant effects for Time × Treatment interaction on total Y-BOCS [F (2.10, 88.42) = 8.66, p < 0.001], obsession [F (1.88, 79.34) = 4.96, p = 0.01] and compulsion [F (1.88, 79.11) = 4.57, p = 0.01]. At week 10, the change from baseline in Y-BOCS scores was 8.86 ± 2.89 (mean ± SD) in the L-carnosine group compared to 5.86 ± 2.88 in the placebo group. Conclusion: L-carnosine results in significant reduction of obsessive-compulsive symptoms when used as an adjuvant to fluvoxamine. Copyright © 2017 John Wiley & Sons, Ltd.
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