Minocycline Combination Therapy With Fluvoxamine in Moderate-To-Severe Obsessive–Compulsive Disorder: A Placebo-Controlled, Double-Blind, Randomized Trial

Minocycline Combination Therapy With Fluvoxamine in Moderate-To-Severe Obsessive–Compulsive Disorder: A Placebo-Controlled, Double-Blind, Randomized Trial Publisher Pubmed

Esalatmanesh S¹ ; Abrishami Z¹ ; Zeinoddini A¹ ; Rahiminejad F¹ ; Sadeghi M¹ ; Najarzadegan MR² ; Shalbafan MR² ; Akhondzadeh S¹

Show Affiliations

1. Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran
2. Mental Health Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Psychiatry and Clinical Neurosciences Published:2016

Abstract

Aim: Several lines of evidence implicate glutamatergic dysfunction in the pathophysiology of obsessive–compulsive disorder (OCD), presenting this neurotransmitter as a target for the development of novel pharmacotherapy. The objective of this study was to assess the efficacy of minocycline as an augmentative agent to fluvoxamine in the treatment of patients with OCD. Methods: One hundred and two patients with the diagnosis of moderate-to-severe OCD were recruited to this study. A randomized double-blind trial was designed and patients received either L-carnosine or placebo as adjuvant to fluvoxamine for 10 weeks. The patients randomly received either minocycline 100 mg twice per day or placebo for 10 weeks. All patients received fluvoxamine (100 mg/day) for the first 4 weeks, followed by 200 mg/day for the rest of the trial, regardless of their treatment groups. Participants were evaluated using the Yale–Brown Obsessive Compulsive Scale (Y-BOCS). The main outcome measure was to assess the efficacy of minocycline in improving the OCD symptoms. Results: General linear model repeated measures demonstrated significant effect for time × treatment interaction on the Y-BOCS total scores, F(1.49, 137.93) = 7.1, P = 0.003, and Y-BOCS Obsession subscale score, F(1.54, 141.94) = 9.72, P = 0.001, and near significant effect for the Y-BOCS Compulsion subscale score, F(1.27, 117.47) = 2.92, P = 0.08. A significantly greater rate of partial and complete response was observed in the minocycline group (P < 0.001). The frequency of side-effects was not significantly different between the treatment arms. Conclusion: The results of this study suggest that minocycline could be a tolerable and effective adjuvant in the management of patients with OCD. © 2016 The Authors. Psychiatry and Clinical Neurosciences © 2016 Japanese Society of Psychiatry and Neurology

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Style	Citing Format
MLA	Esalatmanesh S, et al.. "Minocycline Combination Therapy With Fluvoxamine in Moderate-To-Severe Obsessive–Compulsive Disorder: A Placebo-Controlled, Double-Blind, Randomized Trial." Psychiatry and Clinical Neurosciences, vol. 70, no. 11, 2016, pp. 517-526.
APA	Esalatmanesh S, Abrishami Z, Zeinoddini A, Rahiminejad F, Sadeghi M, Najarzadegan MR, Shalbafan MR, Akhondzadeh S (2016). Minocycline Combination Therapy With Fluvoxamine in Moderate-To-Severe Obsessive–Compulsive Disorder: A Placebo-Controlled, Double-Blind, Randomized Trial. Psychiatry and Clinical Neurosciences, 70(11), 517-526.
Chicago	Esalatmanesh S, Abrishami Z, Zeinoddini A, Rahiminejad F, Sadeghi M, Najarzadegan MR, Shalbafan MR, Akhondzadeh S. "Minocycline Combination Therapy With Fluvoxamine in Moderate-To-Severe Obsessive–Compulsive Disorder: A Placebo-Controlled, Double-Blind, Randomized Trial." Psychiatry and Clinical Neurosciences 70, no. 11 (2016): 517-526.
Harvard	Esalatmanesh S et al. (2016) 'Minocycline Combination Therapy With Fluvoxamine in Moderate-To-Severe Obsessive–Compulsive Disorder: A Placebo-Controlled, Double-Blind, Randomized Trial', Psychiatry and Clinical Neurosciences, 70(11), pp. 517-526.
Vancouver	Esalatmanesh S, Abrishami Z, Zeinoddini A, Rahiminejad F, Sadeghi M, Najarzadegan MR, et al.. Minocycline Combination Therapy With Fluvoxamine in Moderate-To-Severe Obsessive–Compulsive Disorder: A Placebo-Controlled, Double-Blind, Randomized Trial. Psychiatry and Clinical Neurosciences. 2016;70(11):517-526.
BibTex	@article{ author = {Esalatmanesh S and Abrishami Z and Zeinoddini A and Rahiminejad F and Sadeghi M and Najarzadegan MR and Shalbafan MR and Akhondzadeh S}, title = {Minocycline Combination Therapy With Fluvoxamine in Moderate-To-Severe Obsessive–Compulsive Disorder: A Placebo-Controlled, Double-Blind, Randomized Trial}, journal = {Psychiatry and Clinical Neurosciences}, volume = {70}, number = {11}, pages = {517-526}, year = {2016} }
RIS	TY - JOUR AU - Esalatmanesh S AU - Abrishami Z AU - Zeinoddini A AU - Rahiminejad F AU - Sadeghi M AU - Najarzadegan MR AU - Shalbafan MR AU - Akhondzadeh S TI - Minocycline Combination Therapy With Fluvoxamine in Moderate-To-Severe Obsessive–Compulsive Disorder: A Placebo-Controlled, Double-Blind, Randomized Trial JO - Psychiatry and Clinical Neurosciences VL - 70 IS - 11 SP - 517 EP - 526 PY - 2016 ER -

Style

Citing Format

MLA

Esalatmanesh S, et al.. "Minocycline Combination Therapy With Fluvoxamine in Moderate-To-Severe Obsessive–Compulsive Disorder: A Placebo-Controlled, Double-Blind, Randomized Trial." Psychiatry and Clinical Neurosciences, vol. 70, no. 11, 2016, pp. 517-526.

APA

Esalatmanesh S, Abrishami Z, Zeinoddini A, Rahiminejad F, Sadeghi M, Najarzadegan MR, Shalbafan MR, Akhondzadeh S (2016). Minocycline Combination Therapy With Fluvoxamine in Moderate-To-Severe Obsessive–Compulsive Disorder: A Placebo-Controlled, Double-Blind, Randomized Trial. Psychiatry and Clinical Neurosciences, 70(11), 517-526.

Chicago

Esalatmanesh S, Abrishami Z, Zeinoddini A, Rahiminejad F, Sadeghi M, Najarzadegan MR, Shalbafan MR, Akhondzadeh S. "Minocycline Combination Therapy With Fluvoxamine in Moderate-To-Severe Obsessive–Compulsive Disorder: A Placebo-Controlled, Double-Blind, Randomized Trial." Psychiatry and Clinical Neurosciences 70, no. 11 (2016): 517-526.

Harvard

Esalatmanesh S et al. (2016) 'Minocycline Combination Therapy With Fluvoxamine in Moderate-To-Severe Obsessive–Compulsive Disorder: A Placebo-Controlled, Double-Blind, Randomized Trial', Psychiatry and Clinical Neurosciences, 70(11), pp. 517-526.

Vancouver

Esalatmanesh S, Abrishami Z, Zeinoddini A, Rahiminejad F, Sadeghi M, Najarzadegan MR, et al.. Minocycline Combination Therapy With Fluvoxamine in Moderate-To-Severe Obsessive–Compulsive Disorder: A Placebo-Controlled, Double-Blind, Randomized Trial. Psychiatry and Clinical Neurosciences. 2016;70(11):517-526.

BibTex

@article{ author = {Esalatmanesh S and Abrishami Z and Zeinoddini A and Rahiminejad F and Sadeghi M and Najarzadegan MR and Shalbafan MR and Akhondzadeh S}, title = {Minocycline Combination Therapy With Fluvoxamine in Moderate-To-Severe Obsessive–Compulsive Disorder: A Placebo-Controlled, Double-Blind, Randomized Trial}, journal = {Psychiatry and Clinical Neurosciences}, volume = {70}, number = {11}, pages = {517-526}, year = {2016} }

RIS

TY - JOUR
AU - Esalatmanesh S
AU - Abrishami Z
AU - Zeinoddini A
AU - Rahiminejad F
AU - Sadeghi M
AU - Najarzadegan MR
AU - Shalbafan MR
AU - Akhondzadeh S
TI - Minocycline Combination Therapy With Fluvoxamine in Moderate-To-Severe Obsessive–Compulsive Disorder: A Placebo-Controlled, Double-Blind, Randomized Trial
JO - Psychiatry and Clinical Neurosciences
VL - 70
IS - 11
SP - 517
EP - 526
PY - 2016
ER -

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Abstract