Diagnostic Accuracy of Artificial Intelligence Models in Detecting Osteoporosis Using Dental Images: A Systematic Review and Meta-Analysis Publisher Pubmed



Khadivi G¹ ; Akhtari A² ; Sharifi F³ ; Zargarian N⁴ ; Esmaeili S⁵ ; Ahsaie MG¹ ; Shahbazi S⁶ Show Affiliations
Source: Osteoporosis International Published:2025

Abstract

The current study aimed to systematically review the literature on the accuracy of artificial intelligence (AI) models for osteoporosis (OP) diagnosis using dental images. A thorough literature search was executed in October 2022 and updated in November 2023 across multiple databases, including PubMed, Scopus, Web of Science, and Google Scholar. The research targeted studies using AI models for OP diagnosis from dental radiographs. The main outcomes were the sensitivity and specificity of AI models regarding OP diagnosis. The “meta” package from the R Foundation was selected for statistical analysis. A random-effects model, along with 95% confidence intervals, was utilized to estimate pooled values. The Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool was employed for risk of bias and applicability assessment. Among 640 records, 22 studies were included in the qualitative analysis and 12 in the meta-analysis. The overall sensitivity for AI-assisted OP diagnosis was 0.85 (95% CI, 0.70–0.93), while the pooled specificity equaled 0.95 (95% CI, 0.91–0.97). Conventional algorithms led to a pooled sensitivity of 0.82 (95% CI, 0.57–0.94) and a pooled specificity of 0.96 (95% CI, 0.93–0.97). Deep convolutional neural networks exhibited a pooled sensitivity of 0.87 (95% CI, 0.68–0.95) and a pooled specificity of 0.92 (95% CI, 0.83–0.96). This systematic review corroborates the accuracy of AI in OP diagnosis using dental images. Future research should expand sample sizes in test and training datasets and standardize imaging techniques to establish the reliability of AI-assisted methods in OP diagnosis through dental images. © International Osteoporosis Foundation and Bone Health and Osteoporosis Foundation 2024.