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Oral Cancer: A Multicenter Study Publisher Pubmed



Dhanuthai K1 ; Rojanawatsirivej S1 ; Thosaporn W2 ; Kintarak S3 ; Subarnbhesaj A4 ; Darling M5 ; Kryshtalskyj E5 ; Chiang CP6 ; Shin HI7 ; Choi SY8 ; Lee SS9 ; Shakib PA10
Authors
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Authors Affiliations
  1. 1. Department of oral Pathology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand
  2. 2. Department of Oral Biology and Oral Diagnostic Sciences, Faculty of Dentistry, Chiangmai University, Chiangmai, Thailand
  3. 3. Department of Stomatology, Faculty of Dentistry, Prince of Songkla University, Songkhla, Thailand
  4. 4. Department of Oral Diagnosis, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand
  5. 5. Department of Pathology and Laboratory Medicine, Western University, London, Canada
  6. 6. Department of Oral Pathology and Oral Diagnosis, School of Dentistry, National Taiwan University, Taiwan
  7. 7. Department of Oral Pathology, School of Dentistry, Kyungpook National University, Daegu, South Korea
  8. 8. Department of Oral & Maxillofacial Surgery, School of Dentistry, Kyungpook National University, Daegu, South Korea
  9. 9. Department of Oral Pathology, School of Dentistry, Gangneung-Wonju National University, Gangneung, South Korea
  10. 10. Department of Oral and Maxillofacial Pathology, School of Dentistry, University of Medical Sciences, Tehran, Iran

Source: Medicina Oral Patologia Oral y Cirugia Bucal Published:2018


Abstract

Background: To determine the prevalence and clinicopathologic features of the oral cancer patients. Material and Methods: Biopsy records of the participating institutions were reviewed for oral cancer cases diagnosed from 2005 to 2014. Demographic data and site of the lesions were collected. Sites of the lesion were subdivided into lip, tongue, floor of the mouth, gingiva, alveolar mucosa, palate, buccal/labial mucosa, maxilla and mandible. Oral cancer was subdivided into 7 categories: epithelial tumors, salivary gland tumors, hematologic tumors, bone tumors, mesenchymal tumors, odontogenic tumors, and others. Data were analyzed by descriptive statistics using SPSS software version 17.0. Results: Of the 474,851 accessioned cases, 6,151 cases (1.30%) were diagnosed in the category of oral cancer. The mean age of the patients was 58.37±15.77 years. A total of 4,238 cases (68.90%) were diagnosed in males, whereas 1911 cases (31.07%) were diagnosed in females. The male-to-female ratio was 2.22:1. The sites of predilection for oral cancer were tongue, labial/buccal mucosa, gingiva, palate, and alveolar mucosa, respectively. The three most common oral cancer in the descending order of frequency were squamous cell carcinoma, non-Hodgkin lymphoma and mucoepidermoid carcinoma. Conclusions: Although the prevalence of oral cancer is not high compared to other entities, oral cancer pose significant mortality and morbidity in the patients, especially when discovered late in the course of the disease. This study highlights some anatomical locations where oral cancers are frequently encountered. As a result, clinicians should pay attention to not only teeth, but oral mucosa especially in the high prevalence area as well since early detection of precancerous lesions or cancers in the early stage increase the chance of patient being cured and greatly reduce the mortality and morbidity. This study also shows some differences between pediatric and elderly oral cancer patients as well as between Asian and non-Asian oral cancer patients. © Medicina Oral S. L. C.I.F.
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