Oral Health and Risk of Upper Gastrointestinal Cancers in a Large Prospective Study From a High-Risk Region: Golestan Cohort Study

Oral Health and Risk of Upper Gastrointestinal Cancers in a Large Prospective Study From a High-Risk Region: Golestan Cohort Study Publisher Pubmed

Yano Y¹ ; Abnet CC¹ ; Poustchi H^{2, 3} ; Roshandel G⁴ ; Pourshams A^{2, 3} ; Islami F^{3, 5} ; Khoshnia M⁴ ; Amiriani T⁴ ; Norouzi A⁴ ; Kamangar F⁶ ; Boffetta P^{7, 8} ; Brennan P⁹ ; Dawsey SM¹ ; Vogtmann E¹ Show All Authors

Yano Y¹
Abnet CC¹
Poustchi H^{2, 3}
Roshandel G⁴
Pourshams A^{2, 3}
Islami F^{3, 5}
Khoshnia M⁴
Amiriani T⁴
Norouzi A⁴
Kamangar F⁶
Boffetta P^{7, 8}
Brennan P⁹
Dawsey SM¹
Vogtmann E¹
Malekzadeh R^{2, 3}
Etemadi A^{1, 3}

Show Affiliations

1. Division of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, MD, United States
2. Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
3. Diges-tive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
4. Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran
5. Data Science Program, American Cancer Society, Atlanta, GA, United States
6. Department of Biology, School of Computer, Mathematical, and Natural Sciences, Morgan State University, Baltimore, MD, United States
7. Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, United States
8. Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
9. Section of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France

Source: Cancer Prevention Research Published:2021

Abstract

Tooth loss and periodontal disease have been associated with several cancers, and poor oral health may be an important risk factor for upper gastrointestinal (UGI, i.e., esophageal and gastric) cancers. We assessed the relationship between oral health and UGI cancers using a large prospective study of over 50,000 adults living in Golestan Province, Iran, a high-incidence area for these cancers. Hazard ratios (HRs) and 95% confidence intervals (CI) were estimated for the association between three different measures of oral health [frequency of tooth brushing; number of missing teeth; and the sum of decayed, missing, and filled teeth (DMFT)] and UGI cancers. During a median follow-up duration of 13 years, there were 794 incident UGI cancers (396 esophageal and 398 gastric cancers). Daily tooth brushing was associated with a decreased risk of developing both esophageal (HR ¼ 0.670; 95% CI: 0.486–0.924) and gastric (HR ¼ 0.741; 95% CI: 0.544–1.01) cancers (combined UGI cancer HR ¼ 0.697; 95% CI: 0.558–0.871) compared with never brushing. Tooth loss in excess of the loess smoothed, age- and sex-specific median number of teeth lost was significantly associated with esophageal (HR ¼ 1.64; 95% CI: 1.08–2.47) and gastric cancers (HR ¼ 1.58; 95% CI: 1.05–2.38). There were some adverse associations between DMFT and UGI cancers but most were not statistically significant. These results suggest increased risk of developing UGI cancers among individuals with poor oral health, and those who do not perform regular oral hygiene. Prevention Relevance: Poor oral health is associated with the risk of upper gastrointestinal cancers, and oral hygiene practices may help prevent these cancers. © 2021 American Association for Cancer Research.

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Reza Malekzadeh (96)

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Style	Citing Format
MLA	Yano Y, et al.. "Oral Health and Risk of Upper Gastrointestinal Cancers in a Large Prospective Study From a High-Risk Region: Golestan Cohort Study." Cancer Prevention Research, vol. 14, no. 7, 2021, pp. 709-718.
APA	Yano Y, Abnet CC, Poustchi H, Roshandel G, Pourshams A, Islami F, Khoshnia M, Amiriani T, Norouzi A, Kamangar F, Boffetta P, Brennan P, Dawsey SM, Vogtmann E, Malekzadeh R, Etemadi A (2021). Oral Health and Risk of Upper Gastrointestinal Cancers in a Large Prospective Study From a High-Risk Region: Golestan Cohort Study. Cancer Prevention Research, 14(7), 709-718.
Chicago	Yano Y, Abnet CC, Poustchi H, Roshandel G, Pourshams A, Islami F, Khoshnia M, et al.. "Oral Health and Risk of Upper Gastrointestinal Cancers in a Large Prospective Study From a High-Risk Region: Golestan Cohort Study." Cancer Prevention Research 14, no. 7 (2021): 709-718.
Harvard	Yano Y et al. (2021) 'Oral Health and Risk of Upper Gastrointestinal Cancers in a Large Prospective Study From a High-Risk Region: Golestan Cohort Study', Cancer Prevention Research, 14(7), pp. 709-718.
Vancouver	Yano Y, Abnet CC, Poustchi H, Roshandel G, Pourshams A, Islami F, et al.. Oral Health and Risk of Upper Gastrointestinal Cancers in a Large Prospective Study From a High-Risk Region: Golestan Cohort Study. Cancer Prevention Research. 2021;14(7):709-718.
BibTex	@article{ author = {Yano Y and Abnet CC and Poustchi H and Roshandel G and Pourshams A and Islami F and Khoshnia M and Amiriani T and Norouzi A and Kamangar F and Boffetta P and Brennan P and Dawsey SM and Vogtmann E and Malekzadeh R and Etemadi A}, title = {Oral Health and Risk of Upper Gastrointestinal Cancers in a Large Prospective Study From a High-Risk Region: Golestan Cohort Study}, journal = {Cancer Prevention Research}, volume = {14}, number = {7}, pages = {709-718}, year = {2021} }
RIS	TY - JOUR AU - Yano Y AU - Abnet CC AU - Poustchi H AU - Roshandel G AU - Pourshams A AU - Islami F AU - Khoshnia M AU - Amiriani T AU - Norouzi A AU - Kamangar F AU - Boffetta P AU - Brennan P AU - Dawsey SM AU - Vogtmann E AU - Malekzadeh R AU - Etemadi A TI - Oral Health and Risk of Upper Gastrointestinal Cancers in a Large Prospective Study From a High-Risk Region: Golestan Cohort Study JO - Cancer Prevention Research VL - 14 IS - 7 SP - 709 EP - 718 PY - 2021 ER -

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