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Anti –Inflammatory Effect of Methanolic and Aqueous Extracts of Urtica Pilulifera L. Seed in Rats Publisher



Abbassian A1 ; Massoud A2 ; Naseri M3 ; Kamalinejad M4 ; Mohsenimoghaddam P5 ; Emadi F3 ; Zargaran A6, 7
Authors
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Authors Affiliations
  1. 1. Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran
  4. 4. Faculty of Pharmacy, Shahid Beheshti University, Tehran, Iran
  5. 5. Department of Traditional Physiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  6. 6. Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of History of Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Traditional and Integrative Medicine Published:2023


Abstract

Wide range of acute and chronic inflammatory ailments, side effects of their available therapies and incomplete treatment of such patients push the researches to find new and more effective drugs. To reach this aim, in the current study, we evaluate Urtica pilulifera L. (family Urticaceae) as an introduced traditional herb for treatment of inflammation in Persian Medicine (PM). In an animal study, Anti-inflammatory effects of U. pilulifera were assessed in formalin-induced hind paw edema in rats. Sodium salicylate (300 mg/kg, i.p., SS) injection was used as a positive control drug and compared with methanolic extract of U. pilulifera (20 mg/kg; i.p.) (MUP), three different doses of aqueous extract of U. pilulifera (20, 40 and 80 mg/ kg; i.p.) (AUP) and a group of distilled water (6 mL/kg; i.p.). As acute anti-inflammatory effect, AUP in doses 40 and 80 mg/kg decreased edema significantly (p<0.05). In chronic anti-inflammatory response, results indicated that all AUP doses had anti-inflammatory effects (p <0.05) with no significant difference with SS group. In conclusion, AUP had anti-inflammatory effects on both acute and chronic edema; while MUP was only effective in chronic inflammation. Copyright © 2023 Tehran University of Medical Sciences.