Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Co-Infection of St2ip Carbapenem-Resistant Acinetobacter Baumannii With Sars-Cov-2 in the Patients Admitted to a Tehran Tertiary Referral Hospital Publisher Pubmed



Abdollahi A1 ; Aliramezani A1 ; Salehi M2 ; Norouzi Shadehi M2 ; Ghourchian S3 ; Douraghi M3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pathology, School of Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Infectious Disease, School of Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Division of Microbiology, Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, PO Box: 14155-6446, Tehran, Iran

Source: BMC Infectious Diseases Published:2021


Abstract

Background: Carbapenem-resistant Acinetobacter baumannii (CRAB) is among the most concerning cause of healthcare-associated infections (HAI) due to its high level of antibiotic resistance and high mortality. In the era of the COVID-19 pandemic, the key priority of infection control committees is to contain the dissemination of antibiotic resistant Gram-negative bacteria. Here, we aimed to timely recognize the emergence of CRAB in COVID-19 cases admitted to the wards of a tertiary referral hospital and to identify the genetic relatedness of the isolates. Methods: From 30 March to 30 May 2020, a total of 242 clinical samples from COVID-19 cases were screened for CRAB isolates using standard microbiologic and antibiotic susceptibility tests. The PCRs targeting oxa23, oxa24, oxa58, blaTEM and blaNDM-1 genes were performed. Two multiplex PCRs for identifying the global clones (GC) of A. baumannii were also performed. The sequence type of CRABs was determined using Institut Pasteur (IP) multilocus sequence typing (MLST) scheme. Results: Eighteen CRAB isolates were recovered from COVID-19 patients with the mean age of 63.94 ± 13.8 years. All but 4 COVID-19 patients co-infected with CRAB were suffering from an underlying disease. Death was recorded as the outcome in ICUs for 9 (50%) COVID-19 patients co-infected with CRAB. The CRAB isolates belong to GC2 and ST2IP and carried the oxa23 carbapenem resistance gene. Conclusion: This study demonstrated the co-infection of CRAB isolates and SARS-CoV-2 in the patients admitted to different ICUs at a referral hospital in Tehran. The CRAB isolates were found to belong to ST2IP, share the oxa23 gene and to have caused several outbreaks in the wards admitting COVID-19 patients. © 2021, The Author(s).
Related Docs
View other Related Docs
1. The Context of Blaoxa−23 Gene in Iraqi Carbapenem-Resistant Acinetobacter Baumannii Isolates Belonging to Global Clone 1 and Global Clone 2, BMC Research Notes (2024)
2. Accumulation of Antibiotic Resistance Genes in Carbapenem-Resistant Acinetobacter Baumannii Isolates Belonging to Lineage 2, Global Clone 1, From Outbreaks in 2012-2013 at a Tehran Burns Hospital, mSphere (2020)
3. Plasmid Borne Carbapenem-Hydrolyzing Class D Β-Lactamases (Chdls) and Adeabc Efflux Pump Conferring Carbapenem-Tigecycline Resistance Among Acinetobacter Baumannii Isolates Harboring Tnabars, Microbial Pathogenesis (2017)
4. Dissemination of the Acinetobacter Baumannii Isolates Belonging to Global Clone 2 Containing Abgri Resistance Islands in a Referral Hospital, Microbiology Spectrum (2023)
5. Two Carbapenem-Resistant St1:St231:Kl1:Ocl1 Acinetobacter Baumannii Strains Recovered in Tehran, Iran, Carry Abar31 in the Chromosome and Abar4 and Tnapha6 in a Repaci6 Plasmid, JAC-Antimicrobial Resistance (2021)
6. Wide Distribution of Carbapenem Resistant Acinetobacter Baumannii in Burns Patients in Iran, Frontiers in Microbiology (2015)
7. Genetic Diversity of Oxa Producing Carbapenem-Resistant Acinetobacter Baumannii From Environment of Tertiary Hospitals in Central Iran, Archives of Clinical Infectious Diseases (2020)
8. Acinetobacter Baumannii Infection in Critically Ill Patients With Covid-19 From Tehran, Iran: The Prevalence, Antimicrobial Resistance Patterns and Molecular Characteristics of Isolates, Frontiers in Cellular and Infection Microbiology (2024)
Experts (# of related papers)
View all Related Experts
Masoumeh Douraghi (8)
Abbas Bahador (4)
Other Related Docs
9. Evidence of Interruption of the Comm Gene in a Large Series of Clinical Isolates of Multidrug-Resistant Acinetobacter Baumannii, Journal of Molecular Microbiology and Biotechnology (2016)
10. Amikacin Resistance Due to the Apha6 Gene in Multi-Antibiotic Resistant Acinetobacter Baumannii Isolates Belonging to Global Clone 1 From Iran, BMC Microbiology (2019)
11. Genotypic and Antimicrobial Susceptibility of Carbapenem-Resistant Acinetobacter Baumannii: Analysis of Is Aba Elements and Blaoxa-23-Like Genes Including a New Variant, Frontiers in Microbiology (2015)
12. Sub-Minimum Inhibitory Concentrations (Sub-Mics) of Colistin on Acinetobacter Baumannii Biofilm Formation Potency, Adherence, and Invasion to Epithelial Host Cells: An Experimental Study in an Iranian Children’S Referral Hospital, Microbiology Spectrum (2024)
13. Mobile Genetic Elements Carrying Aminoglycoside Resistance Genes in Acinetobacter Baumannii Isolates Belonging to Global Clone 2, Frontiers in Microbiology (2023)
14. First Report of Oxa-143-Lactamase Producing Acinetobacter Baumannii in Qom, Iran, Iranian Journal of Basic Medical Sciences (2017)
15. Acquisition of Tn6018-3′ Cs Regions Increases Colistin Mics Against Acinetobacter Baumannii Isolates Harboring New Variants of Abars, Folia Microbiologica (2017)