Effects of Zinc, Vitamin D, and Their Co-Supplementation on Mood, Serum Cortisol, and Brain-Derived Neurotrophic Factor in Patients With Obesity and Mild to Moderate Depressive Symptoms: A Phase Ii, 12-Wk, 2 × 2 Factorial Design, Double-Blind, Randomized, Placebo-Controlled Trial

Effects of Zinc, Vitamin D, and Their Co-Supplementation on Mood, Serum Cortisol, and Brain-Derived Neurotrophic Factor in Patients With Obesity and Mild to Moderate Depressive Symptoms: A Phase Ii, 12-Wk, 2 × 2 Factorial Design, Double-Blind, Randomized, Placebo-Controlled Trial Publisher Pubmed

Yosaee S^{1, 2, 3} ; Soltani S^{4, 5} ; Esteghamati A⁶ ; Motevalian SA⁷ ; Tehranidoost M⁸ ; Clark CCT⁹ ; Jazayeri S^{1, 10}

Show Affiliations

1. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
2. Department of Nutrition, School of Health, Larestan University of Medical Sciences, Larestan, Iran
3. Department of Nutrition, Emam Reza Teaching Hospital, Larestan University of Medical Sciences, Larestan, Iran
4. Department of Nutrition, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
5. Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
6. Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
7. Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
8. Department of Psychiatry School of Medicine, Roozbeh Psychiatry Hospital Tehran University of Medical Sciences, Tehran, Iran
9. Centre for Sport, Exercise and Life Sciences, Coventry University, Coventry, United Kingdom
10. Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology & Metabolism, Iran University of Medical Sciences, Tehran, Iran

Source: Nutrition Published:2020

Abstract

Objective: The aim of this study was to investigate the effects of zinc, vitamin D, and their co-supplementation versus placebo on changes in the Beck Depression Inventory II (BDI-II) score, serum cortisol level, and brain-derived neurotrophic factor (BDNF) in obese/overweight patients with depressive symptoms. Method: This 2 × 2 factorial, double-blind, randomized, placebo-controlled trial with obese/overweight patients with depressive symptoms was conducted in the Endocrinology and Metabolism Research Center (EMRC), Vali-Asr, Emam Khomeini Hospital between July 2016 and February 2017. The intervention period was 12 wk. There were 140 randomized participants who were obese or overweight (mean ± SD, 38.35± 6.70 y of age; mean ± SD body mass index, 30.1 ± 3.78 kg/m2) with BDI ≥ 10. Participants were randomly assigned to one of four groups in a 1:1:1:1 ratio: 2000 IU/d vitamin D + zinc placebo; 30 mg/d zinc gluconate + vitamin D placebo; 2000 IU/d vitamin D + 30 mg/d zinc gluconate; or vitamin D placebo + zinc placebo for 12 wk. Results: We analyzed 125 participants, and a significant decrease in BDI-II was found among those who received zinc, vitamin D, or joint zinc–vitamin D supplements compared with the placebo group (P < 0.001). Zinc was significantly more effective than vitamin D on decreasing the depression score. Supplementation with zinc, vitamin D, or a combination of the two had no significant effects on serum cortisol (P = 0.974) or BDNF (P = 0.076). Fifteen patients discontinued participation owing to pregnancy (n = 1), severe anemia (n = 1), and unspecified unwillingness to continue (n = 13). Conclusion: Supplementation with zinc, vitamin D, or in combination for 12 wk yielded significant beneficial effects on the BDI-II score in obese or overweight patients with BDI-II ≥10. © 2019 Elsevier Inc.

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Khadijeh Mirzaei (3)

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Style	Citing Format
MLA	Yosaee S, et al.. "Effects of Zinc, Vitamin D, and Their Co-Supplementation on Mood, Serum Cortisol, and Brain-Derived Neurotrophic Factor in Patients With Obesity and Mild to Moderate Depressive Symptoms: A Phase Ii, 12-Wk, 2 × 2 Factorial Design, Double-Blind, Randomized, Placebo-Controlled Trial." Nutrition, vol. 71, no. , 2020, pp. -.
APA	Yosaee S, Soltani S, Esteghamati A, Motevalian SA, Tehranidoost M, Clark CCT, Jazayeri S (2020). Effects of Zinc, Vitamin D, and Their Co-Supplementation on Mood, Serum Cortisol, and Brain-Derived Neurotrophic Factor in Patients With Obesity and Mild to Moderate Depressive Symptoms: A Phase Ii, 12-Wk, 2 × 2 Factorial Design, Double-Blind, Randomized, Placebo-Controlled Trial. Nutrition, 71(), -.
Chicago	Yosaee S, Soltani S, Esteghamati A, Motevalian SA, Tehranidoost M, Clark CCT, Jazayeri S. "Effects of Zinc, Vitamin D, and Their Co-Supplementation on Mood, Serum Cortisol, and Brain-Derived Neurotrophic Factor in Patients With Obesity and Mild to Moderate Depressive Symptoms: A Phase Ii, 12-Wk, 2 × 2 Factorial Design, Double-Blind, Randomized, Placebo-Controlled Trial." Nutrition 71, no. (2020): -.
Harvard	Yosaee S et al. (2020) 'Effects of Zinc, Vitamin D, and Their Co-Supplementation on Mood, Serum Cortisol, and Brain-Derived Neurotrophic Factor in Patients With Obesity and Mild to Moderate Depressive Symptoms: A Phase Ii, 12-Wk, 2 × 2 Factorial Design, Double-Blind, Randomized, Placebo-Controlled Trial', Nutrition, 71(), pp. -.
Vancouver	Yosaee S, Soltani S, Esteghamati A, Motevalian SA, Tehranidoost M, Clark CCT, et al.. Effects of Zinc, Vitamin D, and Their Co-Supplementation on Mood, Serum Cortisol, and Brain-Derived Neurotrophic Factor in Patients With Obesity and Mild to Moderate Depressive Symptoms: A Phase Ii, 12-Wk, 2 × 2 Factorial Design, Double-Blind, Randomized, Placebo-Controlled Trial. Nutrition. 2020;71():-.
BibTex	@article{ author = {Yosaee S and Soltani S and Esteghamati A and Motevalian SA and Tehranidoost M and Clark CCT and Jazayeri S}, title = {Effects of Zinc, Vitamin D, and Their Co-Supplementation on Mood, Serum Cortisol, and Brain-Derived Neurotrophic Factor in Patients With Obesity and Mild to Moderate Depressive Symptoms: A Phase Ii, 12-Wk, 2 × 2 Factorial Design, Double-Blind, Randomized, Placebo-Controlled Trial}, journal = {Nutrition}, volume = {71}, number = {}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Yosaee S AU - Soltani S AU - Esteghamati A AU - Motevalian SA AU - Tehranidoost M AU - Clark CCT AU - Jazayeri S TI - Effects of Zinc, Vitamin D, and Their Co-Supplementation on Mood, Serum Cortisol, and Brain-Derived Neurotrophic Factor in Patients With Obesity and Mild to Moderate Depressive Symptoms: A Phase Ii, 12-Wk, 2 × 2 Factorial Design, Double-Blind, Randomized, Placebo-Controlled Trial JO - Nutrition VL - 71 IS - SP - EP - PY - 2020 ER -

Style

Citing Format

MLA

Yosaee S, et al.. "Effects of Zinc, Vitamin D, and Their Co-Supplementation on Mood, Serum Cortisol, and Brain-Derived Neurotrophic Factor in Patients With Obesity and Mild to Moderate Depressive Symptoms: A Phase Ii, 12-Wk, 2 × 2 Factorial Design, Double-Blind, Randomized, Placebo-Controlled Trial." Nutrition, vol. 71, no. , 2020, pp. -.

APA

Yosaee S, Soltani S, Esteghamati A, Motevalian SA, Tehranidoost M, Clark CCT, Jazayeri S (2020). Effects of Zinc, Vitamin D, and Their Co-Supplementation on Mood, Serum Cortisol, and Brain-Derived Neurotrophic Factor in Patients With Obesity and Mild to Moderate Depressive Symptoms: A Phase Ii, 12-Wk, 2 × 2 Factorial Design, Double-Blind, Randomized, Placebo-Controlled Trial. Nutrition, 71(), -.

Chicago

Yosaee S, Soltani S, Esteghamati A, Motevalian SA, Tehranidoost M, Clark CCT, Jazayeri S. "Effects of Zinc, Vitamin D, and Their Co-Supplementation on Mood, Serum Cortisol, and Brain-Derived Neurotrophic Factor in Patients With Obesity and Mild to Moderate Depressive Symptoms: A Phase Ii, 12-Wk, 2 × 2 Factorial Design, Double-Blind, Randomized, Placebo-Controlled Trial." Nutrition 71, no. (2020): -.

Harvard

Yosaee S et al. (2020) 'Effects of Zinc, Vitamin D, and Their Co-Supplementation on Mood, Serum Cortisol, and Brain-Derived Neurotrophic Factor in Patients With Obesity and Mild to Moderate Depressive Symptoms: A Phase Ii, 12-Wk, 2 × 2 Factorial Design, Double-Blind, Randomized, Placebo-Controlled Trial', Nutrition, 71(), pp. -.

Vancouver

Yosaee S, Soltani S, Esteghamati A, Motevalian SA, Tehranidoost M, Clark CCT, et al.. Effects of Zinc, Vitamin D, and Their Co-Supplementation on Mood, Serum Cortisol, and Brain-Derived Neurotrophic Factor in Patients With Obesity and Mild to Moderate Depressive Symptoms: A Phase Ii, 12-Wk, 2 × 2 Factorial Design, Double-Blind, Randomized, Placebo-Controlled Trial. Nutrition. 2020;71():-.

BibTex

@article{ author = {Yosaee S and Soltani S and Esteghamati A and Motevalian SA and Tehranidoost M and Clark CCT and Jazayeri S}, title = {Effects of Zinc, Vitamin D, and Their Co-Supplementation on Mood, Serum Cortisol, and Brain-Derived Neurotrophic Factor in Patients With Obesity and Mild to Moderate Depressive Symptoms: A Phase Ii, 12-Wk, 2 × 2 Factorial Design, Double-Blind, Randomized, Placebo-Controlled Trial}, journal = {Nutrition}, volume = {71}, number = {}, pages = {-}, year = {2020} }

RIS

TY - JOUR
AU - Yosaee S
AU - Soltani S
AU - Esteghamati A
AU - Motevalian SA
AU - Tehranidoost M
AU - Clark CCT
AU - Jazayeri S
TI - Effects of Zinc, Vitamin D, and Their Co-Supplementation on Mood, Serum Cortisol, and Brain-Derived Neurotrophic Factor in Patients With Obesity and Mild to Moderate Depressive Symptoms: A Phase Ii, 12-Wk, 2 × 2 Factorial Design, Double-Blind, Randomized, Placebo-Controlled Trial
JO - Nutrition
VL - 71
IS -
SP -
EP -
PY - 2020
ER -

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